Characterisation of Cyclophilin Proteins from Burkholderia pseudomallei and Their Role in Pathogenesis

Research output: ThesisDoctoral Thesis

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Abstract

Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic in Northern Australia. This study identified two enzymatically active cyclophilin proteins, PpiA and PpiB, as well as characterising their role in pathogenesis. PpiA plays a role in environmental survival and metabolism of B. pseudomallei. PpiB is essential for B. pseudomallei virulence, with deletion causing widespread disruption of the proteome resulting in a lack of cell-to-cell spread in vitro and an inability to cause disease in vivo. PpiB presents as a promising target for the development of anti-virulence compounds against Burkholderia pseudomallei.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Kahler, Charlene, Supervisor
  • Sarkar-Tyson, Mitali, Supervisor
  • Inglis, Tim, Supervisor
Thesis sponsors
Award date1 Nov 2021
DOIs
Publication statusUnpublished - 2021

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