Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)

J. Abimanyi-Ochom, J.J. Watts, F. Borgström, G.C. Nicholson, C. Shore-Lorenti, A.L. Stuart, Y. Zhang, S. Iuliano, E. Seeman, Richard Prince, L. March, M. Cross, T. Winzenberg, L.L. Laslett, G. Duque, P.R. Ebeling, K.M. Sanders

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    Abstract

    Summary: We investigated change in health-related quality of life due to fracture in Australian adults aged over 50 years. Fractures reduce quality of life with the loss sustained at least over 12 months. At a population level, the loss was equivalent to 65 days in full health per fracture.
    Purpose: We aimed to quantify the change in health-related quality of life (HRQoL) that occurred as a consequence of a fracture using the EQ-5D-3 L questionnaire.
    Methods: Adults aged ≥50 years with a low to moderate energy fracture were recruited from eight study centres across Australia. This prospective study included an 18-month follow-up of participants recruited within 2 weeks of a fracture (hip, wrist, humerus, vertebral and ankle). Information collected at baseline and 4, 12 and 18 months included characteristics of participants such as income level, education and prior fracture status. At 12 months post-fracture, the cumulative loss of quality of life was estimated using multivariate regression analysis to identify the predictors of HRQoL loss.
    Results: Mean HRQoL for all participants before fracture was 0.86, with wrist fracture having the highest pre-fracture HRQoL (0.90), while vertebral fracture had the lowest (0.80). HRQoL declined to 0.42 in the immediate post-fracture period. Only participants with a wrist, humerus or ankle fracture returned to their pre-fracture HRQoL after 18 months. An increased loss of HRQoL over 12 months was associated with HRQoL prior to the fracture, hospitalisation, education and fracture site. The multiple regression explained 30 % of the variation in the cumulative HRQoL loss at 12 months post-fracture for all fractures.
    Conclusion: Low to moderate energy fractures reduce HRQoL, and this loss is sustained for at least 12 months or, in the case of hip and spine fractures, at least 18 months. At a population level, this represents an average loss of 65 days in full health per fragility fracture. This significant burden reinforces the need for cost-effective fracture prevention strategies.
    Original languageEnglish
    Pages (from-to)1781-1790
    JournalOsteoporosis International
    Volume26
    Issue number6
    Early online date20 Mar 2015
    DOIs
    Publication statusPublished - Jun 2015

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    Osteoporotic Fractures
    Arm
    Quality of Life
    Costs and Cost Analysis
    Wrist
    Humerus
    Hip Fractures
    Ankle Fractures
    Education
    Health
    Ankle
    Population
    Hospitalization
    Spine

    Cite this

    Abimanyi-Ochom, J. ; Watts, J.J. ; Borgström, F. ; Nicholson, G.C. ; Shore-Lorenti, C. ; Stuart, A.L. ; Zhang, Y. ; Iuliano, S. ; Seeman, E. ; Prince, Richard ; March, L. ; Cross, M. ; Winzenberg, T. ; Laslett, L.L. ; Duque, G. ; Ebeling, P.R. ; Sanders, K.M. / Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). In: Osteoporosis International. 2015 ; Vol. 26, No. 6. pp. 1781-1790.
    @article{06e89ce338b4416f83846d9d14d39c61,
    title = "Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)",
    abstract = "Summary: We investigated change in health-related quality of life due to fracture in Australian adults aged over 50 years. Fractures reduce quality of life with the loss sustained at least over 12 months. At a population level, the loss was equivalent to 65 days in full health per fracture. Purpose: We aimed to quantify the change in health-related quality of life (HRQoL) that occurred as a consequence of a fracture using the EQ-5D-3 L questionnaire. Methods: Adults aged ≥50 years with a low to moderate energy fracture were recruited from eight study centres across Australia. This prospective study included an 18-month follow-up of participants recruited within 2 weeks of a fracture (hip, wrist, humerus, vertebral and ankle). Information collected at baseline and 4, 12 and 18 months included characteristics of participants such as income level, education and prior fracture status. At 12 months post-fracture, the cumulative loss of quality of life was estimated using multivariate regression analysis to identify the predictors of HRQoL loss. Results: Mean HRQoL for all participants before fracture was 0.86, with wrist fracture having the highest pre-fracture HRQoL (0.90), while vertebral fracture had the lowest (0.80). HRQoL declined to 0.42 in the immediate post-fracture period. Only participants with a wrist, humerus or ankle fracture returned to their pre-fracture HRQoL after 18 months. An increased loss of HRQoL over 12 months was associated with HRQoL prior to the fracture, hospitalisation, education and fracture site. The multiple regression explained 30 {\%} of the variation in the cumulative HRQoL loss at 12 months post-fracture for all fractures. Conclusion: Low to moderate energy fractures reduce HRQoL, and this loss is sustained for at least 12 months or, in the case of hip and spine fractures, at least 18 months. At a population level, this represents an average loss of 65 days in full health per fragility fracture. This significant burden reinforces the need for cost-effective fracture prevention strategies.",
    author = "J. Abimanyi-Ochom and J.J. Watts and F. Borgstr{\"o}m and G.C. Nicholson and C. Shore-Lorenti and A.L. Stuart and Y. Zhang and S. Iuliano and E. Seeman and Richard Prince and L. March and M. Cross and T. Winzenberg and L.L. Laslett and G. Duque and P.R. Ebeling and K.M. Sanders",
    year = "2015",
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    doi = "10.1007/s00198-015-3088-z",
    language = "English",
    volume = "26",
    pages = "1781--1790",
    journal = "Osteoporosis International: with other metabolic bone diseases",
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    number = "6",

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    Abimanyi-Ochom, J, Watts, JJ, Borgström, F, Nicholson, GC, Shore-Lorenti, C, Stuart, AL, Zhang, Y, Iuliano, S, Seeman, E, Prince, R, March, L, Cross, M, Winzenberg, T, Laslett, LL, Duque, G, Ebeling, PR & Sanders, KM 2015, 'Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)' Osteoporosis International, vol. 26, no. 6, pp. 1781-1790. https://doi.org/10.1007/s00198-015-3088-z

    Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). / Abimanyi-Ochom, J.; Watts, J.J.; Borgström, F.; Nicholson, G.C.; Shore-Lorenti, C.; Stuart, A.L.; Zhang, Y.; Iuliano, S.; Seeman, E.; Prince, Richard; March, L.; Cross, M.; Winzenberg, T.; Laslett, L.L.; Duque, G.; Ebeling, P.R.; Sanders, K.M.

    In: Osteoporosis International, Vol. 26, No. 6, 06.2015, p. 1781-1790.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)

    AU - Abimanyi-Ochom, J.

    AU - Watts, J.J.

    AU - Borgström, F.

    AU - Nicholson, G.C.

    AU - Shore-Lorenti, C.

    AU - Stuart, A.L.

    AU - Zhang, Y.

    AU - Iuliano, S.

    AU - Seeman, E.

    AU - Prince, Richard

    AU - March, L.

    AU - Cross, M.

    AU - Winzenberg, T.

    AU - Laslett, L.L.

    AU - Duque, G.

    AU - Ebeling, P.R.

    AU - Sanders, K.M.

    PY - 2015/6

    Y1 - 2015/6

    N2 - Summary: We investigated change in health-related quality of life due to fracture in Australian adults aged over 50 years. Fractures reduce quality of life with the loss sustained at least over 12 months. At a population level, the loss was equivalent to 65 days in full health per fracture. Purpose: We aimed to quantify the change in health-related quality of life (HRQoL) that occurred as a consequence of a fracture using the EQ-5D-3 L questionnaire. Methods: Adults aged ≥50 years with a low to moderate energy fracture were recruited from eight study centres across Australia. This prospective study included an 18-month follow-up of participants recruited within 2 weeks of a fracture (hip, wrist, humerus, vertebral and ankle). Information collected at baseline and 4, 12 and 18 months included characteristics of participants such as income level, education and prior fracture status. At 12 months post-fracture, the cumulative loss of quality of life was estimated using multivariate regression analysis to identify the predictors of HRQoL loss. Results: Mean HRQoL for all participants before fracture was 0.86, with wrist fracture having the highest pre-fracture HRQoL (0.90), while vertebral fracture had the lowest (0.80). HRQoL declined to 0.42 in the immediate post-fracture period. Only participants with a wrist, humerus or ankle fracture returned to their pre-fracture HRQoL after 18 months. An increased loss of HRQoL over 12 months was associated with HRQoL prior to the fracture, hospitalisation, education and fracture site. The multiple regression explained 30 % of the variation in the cumulative HRQoL loss at 12 months post-fracture for all fractures. Conclusion: Low to moderate energy fractures reduce HRQoL, and this loss is sustained for at least 12 months or, in the case of hip and spine fractures, at least 18 months. At a population level, this represents an average loss of 65 days in full health per fragility fracture. This significant burden reinforces the need for cost-effective fracture prevention strategies.

    AB - Summary: We investigated change in health-related quality of life due to fracture in Australian adults aged over 50 years. Fractures reduce quality of life with the loss sustained at least over 12 months. At a population level, the loss was equivalent to 65 days in full health per fracture. Purpose: We aimed to quantify the change in health-related quality of life (HRQoL) that occurred as a consequence of a fracture using the EQ-5D-3 L questionnaire. Methods: Adults aged ≥50 years with a low to moderate energy fracture were recruited from eight study centres across Australia. This prospective study included an 18-month follow-up of participants recruited within 2 weeks of a fracture (hip, wrist, humerus, vertebral and ankle). Information collected at baseline and 4, 12 and 18 months included characteristics of participants such as income level, education and prior fracture status. At 12 months post-fracture, the cumulative loss of quality of life was estimated using multivariate regression analysis to identify the predictors of HRQoL loss. Results: Mean HRQoL for all participants before fracture was 0.86, with wrist fracture having the highest pre-fracture HRQoL (0.90), while vertebral fracture had the lowest (0.80). HRQoL declined to 0.42 in the immediate post-fracture period. Only participants with a wrist, humerus or ankle fracture returned to their pre-fracture HRQoL after 18 months. An increased loss of HRQoL over 12 months was associated with HRQoL prior to the fracture, hospitalisation, education and fracture site. The multiple regression explained 30 % of the variation in the cumulative HRQoL loss at 12 months post-fracture for all fractures. Conclusion: Low to moderate energy fractures reduce HRQoL, and this loss is sustained for at least 12 months or, in the case of hip and spine fractures, at least 18 months. At a population level, this represents an average loss of 65 days in full health per fragility fracture. This significant burden reinforces the need for cost-effective fracture prevention strategies.

    U2 - 10.1007/s00198-015-3088-z

    DO - 10.1007/s00198-015-3088-z

    M3 - Article

    VL - 26

    SP - 1781

    EP - 1790

    JO - Osteoporosis International: with other metabolic bone diseases

    JF - Osteoporosis International: with other metabolic bone diseases

    SN - 0937-941X

    IS - 6

    ER -