TY - JOUR
T1 - Changes in periodontal and rheumatological conditions after 2 years in patients with juvenile idiopathic arthritis
AU - Miranda, Letícia A
AU - Braga, Flavia
AU - Fischer, Ricardo G
AU - Sztajnbok, Flávio R
AU - Figueredo, Carlos Marcelo S
AU - Gustafsson, Anders
PY - 2006/10
Y1 - 2006/10
N2 - BACKGROUND: The aim of this study was to monitor changes in periodontal inflammation in patients with juvenile idiopathic arthritis (JIA) for 2 years. We investigated the influence of rheumatic disease activity and antirheumatic medication on clinical and immunological parameters of periodontal inflammation in these individuals.METHODS: Two years after a baseline examination, the periodontal and rheumatological conditions of 18 adolescents with JIA and 14 control subjects were described. The clinical periodontal inflammation was monitored by registration of visual plaque, marginal bleeding, probing depth, and clinical attachment loss (AL). Periodontal inflammation was also assessed by analysis of the cytokines interleukin (IL)-1beta and IL-18 and the collagenase matrix metalloproteinase (MMP)-8 by enzyme-linked immunosorbent assay.RESULTS: The erythrocyte sedimentation rate and clinical rheumatological parameters were significantly improved at the 2-year follow-up. The number of sites with plaque decreased, and the number of pockets >/=4 mm increased, whereas bleeding levels and the extension of AL remained unchanged. IL-1beta in gingival crevicular fluid decreased significantly in the JIA group after 2 years. No differences were observed for IL-1beta, MMP-8, or IL-18 levels between groups after 2 years.CONCLUSION: Two years after the baseline examination, no clinical or laboratory differences in periodontal inflammation could be found between JIA patients and control subjects.
AB - BACKGROUND: The aim of this study was to monitor changes in periodontal inflammation in patients with juvenile idiopathic arthritis (JIA) for 2 years. We investigated the influence of rheumatic disease activity and antirheumatic medication on clinical and immunological parameters of periodontal inflammation in these individuals.METHODS: Two years after a baseline examination, the periodontal and rheumatological conditions of 18 adolescents with JIA and 14 control subjects were described. The clinical periodontal inflammation was monitored by registration of visual plaque, marginal bleeding, probing depth, and clinical attachment loss (AL). Periodontal inflammation was also assessed by analysis of the cytokines interleukin (IL)-1beta and IL-18 and the collagenase matrix metalloproteinase (MMP)-8 by enzyme-linked immunosorbent assay.RESULTS: The erythrocyte sedimentation rate and clinical rheumatological parameters were significantly improved at the 2-year follow-up. The number of sites with plaque decreased, and the number of pockets >/=4 mm increased, whereas bleeding levels and the extension of AL remained unchanged. IL-1beta in gingival crevicular fluid decreased significantly in the JIA group after 2 years. No differences were observed for IL-1beta, MMP-8, or IL-18 levels between groups after 2 years.CONCLUSION: Two years after the baseline examination, no clinical or laboratory differences in periodontal inflammation could be found between JIA patients and control subjects.
KW - Adolescent
KW - Antirheumatic Agents/therapeutic use
KW - Arthritis, Juvenile/drug therapy
KW - Biomarkers/analysis
KW - Blood Sedimentation
KW - Dental Plaque/classification
KW - Female
KW - Follow-Up Studies
KW - Gingival Crevicular Fluid/chemistry
KW - Gingival Hemorrhage/classification
KW - Humans
KW - Interleukin-18/analysis
KW - Interleukin-1beta/analysis
KW - Male
KW - Matrix Metalloproteinase 8/analysis
KW - Periodontal Attachment Loss/classification
KW - Periodontal Pocket/classification
KW - Periodontitis/classification
U2 - 10.1902/jop.2006.060113
DO - 10.1902/jop.2006.060113
M3 - Article
C2 - 17032112
SN - 0022-3492
VL - 77
SP - 1695
EP - 1700
JO - Journal of Periodontology
JF - Journal of Periodontology
IS - 10
ER -