Challenges to curing primary brain tumours

Kenneth Aldape; Kevin M. Brindle; Louis Chesler; Rajesh Chopra; Amar Gajjar; Mark R. Gilbert; Nicholas Gottardo; David H. Gutmann; Darren Hargrave; Eric C. Holland; David T.W. Jones; Johanna A. Joyce; Pamela Kearns; Mark W. Kieran; Ingo K. Mellinghoff; Melinda Merchant; Stefan M. Pfister; Steven M. Pollard; Vijay Ramaswamy; Jeremy N. Rich; Giles W. Robinson; David H. Rowitch; John H. Sampson; Michael D. Taylor; Paul Workman; Richard J. Gilbertson

doi:10.1038/s41571-019-0177-5

Challenges to curing primary brain tumours

Kenneth Aldape, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, David H. Gutmann, Darren Hargrave, Eric C. Holland, David T.W. Jones, Johanna A. Joyce, Pamela Kearns, Mark W. Kieran, Ingo K. Mellinghoff, Melinda Merchant, Stefan M. Pfister, Steven M. Pollard, Vijay Ramaswamy, Jeremy N. RichGiles W. Robinson, David H. Rowitch, John H. Sampson, Michael D. Taylor, Paul Workman, Richard J. Gilbertson

UWA Centre for Child Health Research (affiliated with the Telethon Kids Institute)

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266 Citations (Web of Science)

Abstract

Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

Original language	English
Pages (from-to)	509-520
Number of pages	12
Journal	Nature Reviews Clinical Oncology
Volume	16
Issue number	8
DOIs	https://doi.org/10.1038/s41571-019-0177-5
Publication status	Published - 1 Aug 2019

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Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., Jones, D. T. W., Joyce, J. A., Kearns, P., Kieran, M. W., Mellinghoff, I. K., Merchant, M., Pfister, S. M., Pollard, S. M., Ramaswamy, V., ... Gilbertson, R. J. (2019). Challenges to curing primary brain tumours. Nature Reviews Clinical Oncology, 16(8), 509-520. https://doi.org/10.1038/s41571-019-0177-5

Aldape, Kenneth ; Brindle, Kevin M. ; Chesler, Louis ; Chopra, Rajesh ; Gajjar, Amar ; Gilbert, Mark R. ; Gottardo, Nicholas ; Gutmann, David H. ; Hargrave, Darren ; Holland, Eric C. ; Jones, David T.W. ; Joyce, Johanna A. ; Kearns, Pamela ; Kieran, Mark W. ; Mellinghoff, Ingo K. ; Merchant, Melinda ; Pfister, Stefan M. ; Pollard, Steven M. ; Ramaswamy, Vijay ; Rich, Jeremy N. ; Robinson, Giles W. ; Rowitch, David H. ; Sampson, John H. ; Taylor, Michael D. ; Workman, Paul ; Gilbertson, Richard J. / Challenges to curing primary brain tumours. In: Nature Reviews Clinical Oncology. 2019 ; Vol. 16, No. 8. pp. 509-520.

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title = "Challenges to curing primary brain tumours",

abstract = "Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.",

author = "Kenneth Aldape and Brindle, {Kevin M.} and Louis Chesler and Rajesh Chopra and Amar Gajjar and Gilbert, {Mark R.} and Nicholas Gottardo and Gutmann, {David H.} and Darren Hargrave and Holland, {Eric C.} and Jones, {David T.W.} and Joyce, {Johanna A.} and Pamela Kearns and Kieran, {Mark W.} and Mellinghoff, {Ingo K.} and Melinda Merchant and Pfister, {Stefan M.} and Pollard, {Steven M.} and Vijay Ramaswamy and Rich, {Jeremy N.} and Robinson, {Giles W.} and Rowitch, {David H.} and Sampson, {John H.} and Taylor, {Michael D.} and Paul Workman and Gilbertson, {Richard J.}",

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doi = "10.1038/s41571-019-0177-5",

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Aldape, K, Brindle, KM, Chesler, L, Chopra, R, Gajjar, A, Gilbert, MR, Gottardo, N, Gutmann, DH, Hargrave, D, Holland, EC, Jones, DTW, Joyce, JA, Kearns, P, Kieran, MW, Mellinghoff, IK, Merchant, M, Pfister, SM, Pollard, SM, Ramaswamy, V, Rich, JN, Robinson, GW, Rowitch, DH, Sampson, JH, Taylor, MD, Workman, P & Gilbertson, RJ 2019, 'Challenges to curing primary brain tumours', Nature Reviews Clinical Oncology, vol. 16, no. 8, pp. 509-520. https://doi.org/10.1038/s41571-019-0177-5

Challenges to curing primary brain tumours. / Aldape, Kenneth; Brindle, Kevin M.; Chesler, Louis; Chopra, Rajesh; Gajjar, Amar; Gilbert, Mark R.; Gottardo, Nicholas; Gutmann, David H.; Hargrave, Darren; Holland, Eric C.; Jones, David T.W.; Joyce, Johanna A.; Kearns, Pamela; Kieran, Mark W.; Mellinghoff, Ingo K.; Merchant, Melinda; Pfister, Stefan M.; Pollard, Steven M.; Ramaswamy, Vijay; Rich, Jeremy N.; Robinson, Giles W.; Rowitch, David H.; Sampson, John H.; Taylor, Michael D.; Workman, Paul; Gilbertson, Richard J.

In: Nature Reviews Clinical Oncology, Vol. 16, No. 8, 01.08.2019, p. 509-520.

Research output: Contribution to journal › Article › peer-review

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AU - Aldape, Kenneth

AU - Brindle, Kevin M.

AU - Chesler, Louis

AU - Chopra, Rajesh

AU - Gajjar, Amar

AU - Gilbert, Mark R.

AU - Gottardo, Nicholas

AU - Gutmann, David H.

AU - Hargrave, Darren

AU - Holland, Eric C.

AU - Jones, David T.W.

AU - Joyce, Johanna A.

AU - Kearns, Pamela

AU - Kieran, Mark W.

AU - Mellinghoff, Ingo K.

AU - Merchant, Melinda

AU - Pfister, Stefan M.

AU - Pollard, Steven M.

AU - Ramaswamy, Vijay

AU - Rich, Jeremy N.

AU - Robinson, Giles W.

AU - Rowitch, David H.

AU - Sampson, John H.

AU - Taylor, Michael D.

AU - Workman, Paul

AU - Gilbertson, Richard J.

PY - 2019/8/1

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SP - 509

EP - 520

JO - Nature Reviews Clinical Oncology

JF - Nature Reviews Clinical Oncology

SN - 1743-4254

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ER -

Challenges to curing primary brain tumours

Abstract

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