Abstract
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
| Original language | English |
|---|---|
| Pages (from-to) | 509-520 |
| Journal | Nature Reviews Clinical Oncology |
| Volume | 16 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Challenges to curing primary brain tumours. / Aldape, Kenneth; Brindle, Kevin M.; Chesler, Louis; Chopra, Rajesh; Gajjar, Amar; Gilbert, Mark R.; Gottardo, Nicholas; Gutmann, David H.; Hargrave, Darren; Holland, Eric C.; Jones, David T.W.; Joyce, Johanna A.; Kearns, Pamela; Kieran, Mark W.; Mellinghoff, Ingo K.; Merchant, Melinda; Pfister, Stefan M.; Pollard, Steven M.; Ramaswamy, Vijay; Rich, Jeremy N.; Robinson, Giles W.; Rowitch, David H.; Sampson, John H.; Taylor, Michael D.; Workman, Paul; Gilbertson, Richard J.
In: Nature Reviews Clinical Oncology, Vol. 16, No. 8, 01.01.2019, p. 509-520.Research output: Contribution to journal › Article
TY - JOUR
T1 - Challenges to curing primary brain tumours
AU - Aldape, Kenneth
AU - Brindle, Kevin M.
AU - Chesler, Louis
AU - Chopra, Rajesh
AU - Gajjar, Amar
AU - Gilbert, Mark R.
AU - Gottardo, Nicholas
AU - Gutmann, David H.
AU - Hargrave, Darren
AU - Holland, Eric C.
AU - Jones, David T.W.
AU - Joyce, Johanna A.
AU - Kearns, Pamela
AU - Kieran, Mark W.
AU - Mellinghoff, Ingo K.
AU - Merchant, Melinda
AU - Pfister, Stefan M.
AU - Pollard, Steven M.
AU - Ramaswamy, Vijay
AU - Rich, Jeremy N.
AU - Robinson, Giles W.
AU - Rowitch, David H.
AU - Sampson, John H.
AU - Taylor, Michael D.
AU - Workman, Paul
AU - Gilbertson, Richard J.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
AB - Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
UR - http://www.scopus.com/inward/record.url?scp=85061232481&partnerID=8YFLogxK
U2 - 10.1038/s41571-019-0177-5
DO - 10.1038/s41571-019-0177-5
M3 - Article
VL - 16
SP - 509
EP - 520
JO - Nature Reviews Clinical Oncology
JF - Nature Reviews Clinical Oncology
SN - 1743-4254
IS - 8
ER -