Challenges to curing primary brain tumours

Kenneth Aldape; Kevin M. Brindle; Louis Chesler; Rajesh Chopra; Amar Gajjar; Mark R. Gilbert; Nicholas Gottardo; David H. Gutmann; Darren Hargrave; Eric C. Holland; David T.W. Jones; Johanna A. Joyce; Pamela Kearns; Mark W. Kieran; Ingo K. Mellinghoff; Melinda Merchant; Stefan M. Pfister; Steven M. Pollard; Vijay Ramaswamy; Jeremy N. Rich; Giles W. Robinson; David H. Rowitch; John H. Sampson; Michael D. Taylor; Paul Workman; Richard J. Gilbertson

doi:10.1038/s41571-019-0177-5

Challenges to curing primary brain tumours

Kenneth Aldape, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, David H. Gutmann, Darren Hargrave, Eric C. Holland, David T.W. Jones, Johanna A. Joyce, Pamela Kearns, Mark W. Kieran, Ingo K. Mellinghoff, Melinda Merchant, Stefan M. Pfister, Steven M. Pollard, Vijay Ramaswamy, Jeremy N. RichGiles W. Robinson, David H. Rowitch, John H. Sampson, Michael D. Taylor, Paul Workman, Richard J. Gilbertson

Research output: Contribution to journal › Article

91 Citations (Scopus)

Abstract

Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

Original language	English
Pages (from-to)	509-520
Journal	Nature Reviews Clinical Oncology
Volume	16
Issue number	8
DOIs	https://doi.org/10.1038/s41571-019-0177-5
Publication status	Published - 1 Jan 2019

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Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., Jones, D. T. W., Joyce, J. A., Kearns, P., Kieran, M. W., Mellinghoff, I. K., Merchant, M., Pfister, S. M., Pollard, S. M., Ramaswamy, V., ... Gilbertson, R. J. (2019). Challenges to curing primary brain tumours. Nature Reviews Clinical Oncology, 16(8), 509-520. https://doi.org/10.1038/s41571-019-0177-5

Aldape, Kenneth ; Brindle, Kevin M. ; Chesler, Louis ; Chopra, Rajesh ; Gajjar, Amar ; Gilbert, Mark R. ; Gottardo, Nicholas ; Gutmann, David H. ; Hargrave, Darren ; Holland, Eric C. ; Jones, David T.W. ; Joyce, Johanna A. ; Kearns, Pamela ; Kieran, Mark W. ; Mellinghoff, Ingo K. ; Merchant, Melinda ; Pfister, Stefan M. ; Pollard, Steven M. ; Ramaswamy, Vijay ; Rich, Jeremy N. ; Robinson, Giles W. ; Rowitch, David H. ; Sampson, John H. ; Taylor, Michael D. ; Workman, Paul ; Gilbertson, Richard J. / Challenges to curing primary brain tumours. In: Nature Reviews Clinical Oncology. 2019 ; Vol. 16, No. 8. pp. 509-520.

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abstract = "Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.",

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Aldape, K, Brindle, KM, Chesler, L, Chopra, R, Gajjar, A, Gilbert, MR, Gottardo, N, Gutmann, DH, Hargrave, D, Holland, EC, Jones, DTW, Joyce, JA, Kearns, P, Kieran, MW, Mellinghoff, IK, Merchant, M, Pfister, SM, Pollard, SM, Ramaswamy, V, Rich, JN, Robinson, GW, Rowitch, DH, Sampson, JH, Taylor, MD, Workman, P & Gilbertson, RJ 2019, 'Challenges to curing primary brain tumours', Nature Reviews Clinical Oncology, vol. 16, no. 8, pp. 509-520. https://doi.org/10.1038/s41571-019-0177-5

Challenges to curing primary brain tumours. / Aldape, Kenneth; Brindle, Kevin M.; Chesler, Louis; Chopra, Rajesh; Gajjar, Amar; Gilbert, Mark R.; Gottardo, Nicholas; Gutmann, David H.; Hargrave, Darren; Holland, Eric C.; Jones, David T.W.; Joyce, Johanna A.; Kearns, Pamela; Kieran, Mark W.; Mellinghoff, Ingo K.; Merchant, Melinda; Pfister, Stefan M.; Pollard, Steven M.; Ramaswamy, Vijay; Rich, Jeremy N.; Robinson, Giles W.; Rowitch, David H.; Sampson, John H.; Taylor, Michael D.; Workman, Paul; Gilbertson, Richard J.

In: Nature Reviews Clinical Oncology, Vol. 16, No. 8, 01.01.2019, p. 509-520.

Research output: Contribution to journal › Article

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T1 - Challenges to curing primary brain tumours

AU - Aldape, Kenneth

AU - Brindle, Kevin M.

AU - Chesler, Louis

AU - Chopra, Rajesh

AU - Gajjar, Amar

AU - Gilbert, Mark R.

AU - Gottardo, Nicholas

AU - Gutmann, David H.

AU - Hargrave, Darren

AU - Holland, Eric C.

AU - Jones, David T.W.

AU - Joyce, Johanna A.

AU - Kearns, Pamela

AU - Kieran, Mark W.

AU - Mellinghoff, Ingo K.

AU - Merchant, Melinda

AU - Pfister, Stefan M.

AU - Pollard, Steven M.

AU - Ramaswamy, Vijay

AU - Rich, Jeremy N.

AU - Robinson, Giles W.

AU - Rowitch, David H.

AU - Sampson, John H.

AU - Taylor, Michael D.

AU - Workman, Paul

AU - Gilbertson, Richard J.

PY - 2019/1/1

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