Challenges to curing primary brain tumours

Kenneth Aldape, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, David H. Gutmann, Darren Hargrave, Eric C. Holland, David T.W. Jones, Johanna A. Joyce, Pamela Kearns, Mark W. Kieran, Ingo K. Mellinghoff, Melinda Merchant, Stefan M. Pfister, Steven M. Pollard, Vijay Ramaswamy, Jeremy N. Rich & 6 others Giles W. Robinson, David H. Rowitch, John H. Sampson, Michael D. Taylor, Paul Workman, Richard J. Gilbertson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

Original languageEnglish
Pages (from-to)509-520
JournalNature Reviews Clinical Oncology
Volume16
Issue number8
DOIs
Publication statusPublished - 1 Jan 2019

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Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., ... Gilbertson, R. J. (2019). Challenges to curing primary brain tumours. Nature Reviews Clinical Oncology, 16(8), 509-520. https://doi.org/10.1038/s41571-019-0177-5
Aldape, Kenneth ; Brindle, Kevin M. ; Chesler, Louis ; Chopra, Rajesh ; Gajjar, Amar ; Gilbert, Mark R. ; Gottardo, Nicholas ; Gutmann, David H. ; Hargrave, Darren ; Holland, Eric C. ; Jones, David T.W. ; Joyce, Johanna A. ; Kearns, Pamela ; Kieran, Mark W. ; Mellinghoff, Ingo K. ; Merchant, Melinda ; Pfister, Stefan M. ; Pollard, Steven M. ; Ramaswamy, Vijay ; Rich, Jeremy N. ; Robinson, Giles W. ; Rowitch, David H. ; Sampson, John H. ; Taylor, Michael D. ; Workman, Paul ; Gilbertson, Richard J. / Challenges to curing primary brain tumours. In: Nature Reviews Clinical Oncology. 2019 ; Vol. 16, No. 8. pp. 509-520.
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Aldape, K, Brindle, KM, Chesler, L, Chopra, R, Gajjar, A, Gilbert, MR, Gottardo, N, Gutmann, DH, Hargrave, D, Holland, EC, Jones, DTW, Joyce, JA, Kearns, P, Kieran, MW, Mellinghoff, IK, Merchant, M, Pfister, SM, Pollard, SM, Ramaswamy, V, Rich, JN, Robinson, GW, Rowitch, DH, Sampson, JH, Taylor, MD, Workman, P & Gilbertson, RJ 2019, 'Challenges to curing primary brain tumours' Nature Reviews Clinical Oncology, vol. 16, no. 8, pp. 509-520. https://doi.org/10.1038/s41571-019-0177-5

Challenges to curing primary brain tumours. / Aldape, Kenneth; Brindle, Kevin M.; Chesler, Louis; Chopra, Rajesh; Gajjar, Amar; Gilbert, Mark R.; Gottardo, Nicholas; Gutmann, David H.; Hargrave, Darren; Holland, Eric C.; Jones, David T.W.; Joyce, Johanna A.; Kearns, Pamela; Kieran, Mark W.; Mellinghoff, Ingo K.; Merchant, Melinda; Pfister, Stefan M.; Pollard, Steven M.; Ramaswamy, Vijay; Rich, Jeremy N.; Robinson, Giles W.; Rowitch, David H.; Sampson, John H.; Taylor, Michael D.; Workman, Paul; Gilbertson, Richard J.

In: Nature Reviews Clinical Oncology, Vol. 16, No. 8, 01.01.2019, p. 509-520.

Research output: Contribution to journalArticle

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T1 - Challenges to curing primary brain tumours

AU - Aldape, Kenneth

AU - Brindle, Kevin M.

AU - Chesler, Louis

AU - Chopra, Rajesh

AU - Gajjar, Amar

AU - Gilbert, Mark R.

AU - Gottardo, Nicholas

AU - Gutmann, David H.

AU - Hargrave, Darren

AU - Holland, Eric C.

AU - Jones, David T.W.

AU - Joyce, Johanna A.

AU - Kearns, Pamela

AU - Kieran, Mark W.

AU - Mellinghoff, Ingo K.

AU - Merchant, Melinda

AU - Pfister, Stefan M.

AU - Pollard, Steven M.

AU - Ramaswamy, Vijay

AU - Rich, Jeremy N.

AU - Robinson, Giles W.

AU - Rowitch, David H.

AU - Sampson, John H.

AU - Taylor, Michael D.

AU - Workman, Paul

AU - Gilbertson, Richard J.

PY - 2019/1/1

Y1 - 2019/1/1

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JF - Nature Reviews Clinical Oncology

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Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR et al. Challenges to curing primary brain tumours. Nature Reviews Clinical Oncology. 2019 Jan 1;16(8):509-520. https://doi.org/10.1038/s41571-019-0177-5