Challenges for standardization of Clostridium difficile typing methods

C.A. Huber, Niki Foster, Thomas Riley, D.L. Paterson

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Typing of Clostridium difficile facilitates understanding of the epidemiology of the infection. Some evaluations have shown that certain strain types (for example, ribotype 027) are more virulent than others and are associated with worse clinical outcomes. Although restriction endonuclease analysis (REA) and pulsed-field gel electrophoresis have been widely used in the past, PCR ribotyping is the current method of choice for typing of C. difficile. However, global standardization of ribotyping results is urgently needed. Whole-genome sequencing of C. difficile has the potential to provide even greater epidemiologic information than ribotyping. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)2810-2814
JournalJournal of Clinical Microbiology
Issue number9
Publication statusPublished - 2013


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