Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside

Ziming Chen, Peilin Chen, Monica Zheng, Junjie Gao, Delin Liu, Allan Wang, Qiujian Zheng, Toby Leys, Andrew Tai, Minghao Zheng

Research output: Contribution to journalReview articlepeer-review

Abstract

Tendon is composed of dense fibrous connective tissues, connecting muscle at the myotendinous junction (MTJ) to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Tendon diseases occur at different zones of the tendon, including enthesis, MTJ and midsubstance of the tendon, due to a variety of environmental and genetic factors which consequently result in different frequencies and recovery rates. Self-healing properties of tendons are limited, and cell therapeutic approaches in which injured tendon tissues are renewed by cell replenishment are highly sought after. Homologous use of individual's tendon-derived cells, predominantly differentiated tenocytes and tendon-derived stem cells, is emerging as a treatment for tendinopathy through achieving minimal cell manipulation for clinical use. This is the first review summarizing the progress of tendon-derived cell therapy in clinical use and its challenges due to the structural complexity of tendons, heterogeneous composition of extracellular cell matrix and cells and unsuitable cell sources. Further to that, novel future perspectives to improve therapeutic effect in tendon-derived cell therapy based on current basic knowledge are discussed.

Original languageEnglish
Article number444
Number of pages21
JournalStem Cell Research & Therapy
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2022

Fingerprint

Dive into the research topics of 'Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside'. Together they form a unique fingerprint.

Cite this