Cerebral microbleeds and fatigue in stroke

W. Tang, X. Liu, Y. Chen, J.M. Abrigo, W.C. Chu, V. Mok, Gabor Ungvári, K. Wong

    Research output: Contribution to journalArticle

    7 Citations (Scopus)


    Background and Purpose: Poststroke fatigue (PSF) is a frequent and persistent problem in stroke survivors. The neuroanatomical model of PSF remains unclear. This study examined the association between PSF and cerebral microbleeds (CMBs). Methods: The sample comprised 199 patients with acute ischemic stroke. A psychiatrist who was blind to the subjects' radiological data administered the Chinese version of the Fatigue Severity Scale. PSF was defined as a Fatigue Severity Scale score of 4.0 or more. The locations of CMBs were evaluated with magnetic resonance imaging within 7 days of admission. Results: Of the 199 patients screened, 47 (23.6%) had PSF. The PSF group had a higher Geriatric Depression Scale score (p <0.001) and a trend for a higher age (p = 0.074). The proportion of patients with deep CMBs was significantly higher in the PSF group (66.0 vs. 48.7%; p = 0.038). The presence of deep CMBs was a significant independent predictor of PSF with an odds ratio of 2.68 (p = 0.016). Conclusion: The results suggest that deep CMBs are associated with a higher risk of PSF. Further studies are needed to clarify whether CMBs affect the clinical presentation, treatment response and outcome of PSF. © 2014 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)213-216
    JournalEuropean Neurology
    Issue number5-6
    Publication statusPublished - 2014


    Dive into the research topics of 'Cerebral microbleeds and fatigue in stroke'. Together they form a unique fingerprint.

    Cite this