Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies

Sabine M. Bird, H.R. Sohrabi, T.A. Sutton, Michael Weinborn, S.R. Rainey-Smith, B. Brown, L. Patterson, K. Taddei, V. Gupta, M. Carruthers, N. Lenzo, Neville Knuckey, Romola S. Bucks, Giuseppe Verdile, Ralph N. Martins

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

© 2016 Elsevier Ltd. Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-ß (Aß), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aß levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aß levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p
Original languageEnglish
Pages (from-to)215-228
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume64
DOIs
Publication statusPublished - 2016

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