TY - JOUR
T1 - Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies
AU - Bird, Sabine M.
AU - Sohrabi, H.R.
AU - Sutton, T.A.
AU - Weinborn, Michael
AU - Rainey-Smith, S.R.
AU - Brown, B.
AU - Patterson, L.
AU - Taddei, K.
AU - Gupta, V.
AU - Carruthers, M.
AU - Lenzo, N.
AU - Knuckey, Neville
AU - Bucks, Romola S.
AU - Verdile, Giuseppe
AU - Martins, Ralph N.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - © 2016 Elsevier Ltd. Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-ß (Aß), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aß levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aß levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p
AB - © 2016 Elsevier Ltd. Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-ß (Aß), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aß levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aß levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p
U2 - 10.1016/j.neubiorev.2016.01.004
DO - 10.1016/j.neubiorev.2016.01.004
M3 - Article
C2 - 26899257
SN - 0149-7634
VL - 64
SP - 215
EP - 228
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -