Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies

Sabine M. Bird, H.R. Sohrabi, T.A. Sutton, Michael Weinborn, S.R. Rainey-Smith, B. Brown, L. Patterson, K. Taddei, V. Gupta, M. Carruthers, N. Lenzo, Neville Knuckey, Romola S. Bucks, Giuseppe Verdile, Ralph N. Martins

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

© 2016 Elsevier Ltd. Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-ß (Aß), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aß levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aß levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p
Original languageEnglish
Pages (from-to)215-228
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume64
DOIs
Publication statusPublished - 2016

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Amyloid
Meta-Analysis
Neurodegenerative Diseases
Alzheimer Disease
Serum Amyloid A Protein
Brain Diseases
Animal Models
Traumatic Brain Injury
Wounds and Injuries

Cite this

Bird, Sabine M. ; Sohrabi, H.R. ; Sutton, T.A. ; Weinborn, Michael ; Rainey-Smith, S.R. ; Brown, B. ; Patterson, L. ; Taddei, K. ; Gupta, V. ; Carruthers, M. ; Lenzo, N. ; Knuckey, Neville ; Bucks, Romola S. ; Verdile, Giuseppe ; Martins, Ralph N. / Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. In: Neuroscience and Biobehavioral Reviews. 2016 ; Vol. 64. pp. 215-228.
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Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. / Bird, Sabine M.; Sohrabi, H.R.; Sutton, T.A.; Weinborn, Michael; Rainey-Smith, S.R.; Brown, B.; Patterson, L.; Taddei, K.; Gupta, V.; Carruthers, M.; Lenzo, N.; Knuckey, Neville; Bucks, Romola S.; Verdile, Giuseppe; Martins, Ralph N.

In: Neuroscience and Biobehavioral Reviews, Vol. 64, 2016, p. 215-228.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies

AU - Bird, Sabine M.

AU - Sohrabi, H.R.

AU - Sutton, T.A.

AU - Weinborn, Michael

AU - Rainey-Smith, S.R.

AU - Brown, B.

AU - Patterson, L.

AU - Taddei, K.

AU - Gupta, V.

AU - Carruthers, M.

AU - Lenzo, N.

AU - Knuckey, Neville

AU - Bucks, Romola S.

AU - Verdile, Giuseppe

AU - Martins, Ralph N.

PY - 2016

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AB - © 2016 Elsevier Ltd. Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-ß (Aß), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aß levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aß levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p

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