Extensive efforts have been made to investigate soil–structure interaction (SSI) through numerical simulations whereas little experimental research is reported that tests the applicability of existing numerical models to SSI problems. To provide such experimental data, a unique series of experiments with 3D-printed aluminium framed structures supported by isolated spread footings were conducted in a geotechnical centrifuge. The centrifuge models included equipment and instrumentation that allowed the application of a uniformly distributed static load to the structures as well as the measurement of column loads and foundation movements. The effect of the stiffness of the structure relative to that of the soil was evaluated by varying the number of storeys in the structures and the type/relative density of foundation soils. The variability of soil properties was also studied by modifying the support conditions at single columns at various plan locations of the structure. It is shown that there is appreciable load redistribution in the superstructure, the amount of which depends primarily on the relative structure–soil stiffness and the location of weak and/or rigid foundations. The comparison between the centrifuge test results and the predictions from a simple numerical model with the footings simulated by appropriate linear elastic springs indicates that such a simple numerical model can provide a reasonable prediction of SSI.