Central Nervous System Prophylaxis in Non-Hodgkin Lymphoma: Who, What, and When?

Chan Cheah, John F. Seymour

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Secondary central nervous system (CNS) progression in patients with non-Hodgkin lymphoma (NHL) is associated with a particularly poor prognosis. In this review, we summarize and critically evaluate the current literature to guide the practicing clinician in estimating CNS relapse risk in order to select individual patients who may benefit from CNS prophylaxis, covering histologic subtype, anatomic location, and molecular and clinical factors. We summarize the data regarding different prophylaxis strategies used and provide our recommendation regarding who should receive it, what they should receive, and when it should be administered. © 2015, Springer Science+Business Media New York.
Original languageEnglish
JournalCurrent Oncology Reports
Volume17
Issue number6
Early online date28 Apr 2015
DOIs
Publication statusPublished - 2016
Externally publishedYes

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