Cellulose Biomaterials for Tissue Engineering

Ryan J. Hickey, Andrew E. Pelling

Research output: Contribution to journalReview article

Abstract

In this review, we highlight the importance of nanostructure of cellulose-based biomaterials to allow cellular adhesion, the contribution of nanostructure to macroscale mechanical properties, and several key applications of these materials for fundamental scientific research and biomedical engineering. Different features on the nanoscale can have macroscale impacts on tissue function. Cellulose is a diverse material with tunable properties and is a promising platform for biomaterial development and tissue engineering. Cellulose-based biomaterials offer some important advantages over conventional synthetic materials. Here we provide an up-to-date summary of the status of the field of cellulose-based biomaterials in the context of bottom-up approaches for tissue engineering. We anticipate that cellulose-based material research will continue to expand because of the diversity and versatility of biochemical and biophysical characteristics highlighted in this review.

Original languageEnglish
Article number45
Number of pages15
JournalFrontiers in Bioengineering and Biotechnology
Volume7
Issue numberMAR
DOIs
Publication statusPublished - 22 Mar 2019

Cite this

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title = "Cellulose Biomaterials for Tissue Engineering",
abstract = "In this review, we highlight the importance of nanostructure of cellulose-based biomaterials to allow cellular adhesion, the contribution of nanostructure to macroscale mechanical properties, and several key applications of these materials for fundamental scientific research and biomedical engineering. Different features on the nanoscale can have macroscale impacts on tissue function. Cellulose is a diverse material with tunable properties and is a promising platform for biomaterial development and tissue engineering. Cellulose-based biomaterials offer some important advantages over conventional synthetic materials. Here we provide an up-to-date summary of the status of the field of cellulose-based biomaterials in the context of bottom-up approaches for tissue engineering. We anticipate that cellulose-based material research will continue to expand because of the diversity and versatility of biochemical and biophysical characteristics highlighted in this review.",
keywords = "cellulose, nanostructure, biomaterials, biocompatibility, mechanics, SYNCHROTRON X-RAY, HYDROGEN-BONDING SYSTEM, IN-VITRO EVALUATION, BACTERIAL CELLULOSE, CRYSTAL-STRUCTURE, CELL-ADHESION, COMPOSITE HYDROGEL, BIOMIMETIC GROWTH, CARBON NANOTUBES, NATIVE CELLULOSE",
author = "Hickey, {Ryan J.} and Pelling, {Andrew E.}",
year = "2019",
month = "3",
day = "22",
doi = "10.3389/fbioe.2019.00045",
language = "English",
volume = "7",
journal = "Frontiers in Bioengineering and Biotechnology",
issn = "2296-4185",
publisher = "Frontiers Media SA",
number = "MAR",

}

Cellulose Biomaterials for Tissue Engineering. / Hickey, Ryan J.; Pelling, Andrew E.

In: Frontiers in Bioengineering and Biotechnology, Vol. 7, No. MAR, 45, 22.03.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Cellulose Biomaterials for Tissue Engineering

AU - Hickey, Ryan J.

AU - Pelling, Andrew E.

PY - 2019/3/22

Y1 - 2019/3/22

N2 - In this review, we highlight the importance of nanostructure of cellulose-based biomaterials to allow cellular adhesion, the contribution of nanostructure to macroscale mechanical properties, and several key applications of these materials for fundamental scientific research and biomedical engineering. Different features on the nanoscale can have macroscale impacts on tissue function. Cellulose is a diverse material with tunable properties and is a promising platform for biomaterial development and tissue engineering. Cellulose-based biomaterials offer some important advantages over conventional synthetic materials. Here we provide an up-to-date summary of the status of the field of cellulose-based biomaterials in the context of bottom-up approaches for tissue engineering. We anticipate that cellulose-based material research will continue to expand because of the diversity and versatility of biochemical and biophysical characteristics highlighted in this review.

AB - In this review, we highlight the importance of nanostructure of cellulose-based biomaterials to allow cellular adhesion, the contribution of nanostructure to macroscale mechanical properties, and several key applications of these materials for fundamental scientific research and biomedical engineering. Different features on the nanoscale can have macroscale impacts on tissue function. Cellulose is a diverse material with tunable properties and is a promising platform for biomaterial development and tissue engineering. Cellulose-based biomaterials offer some important advantages over conventional synthetic materials. Here we provide an up-to-date summary of the status of the field of cellulose-based biomaterials in the context of bottom-up approaches for tissue engineering. We anticipate that cellulose-based material research will continue to expand because of the diversity and versatility of biochemical and biophysical characteristics highlighted in this review.

KW - cellulose

KW - nanostructure

KW - biomaterials

KW - biocompatibility

KW - mechanics

KW - SYNCHROTRON X-RAY

KW - HYDROGEN-BONDING SYSTEM

KW - IN-VITRO EVALUATION

KW - BACTERIAL CELLULOSE

KW - CRYSTAL-STRUCTURE

KW - CELL-ADHESION

KW - COMPOSITE HYDROGEL

KW - BIOMIMETIC GROWTH

KW - CARBON NANOTUBES

KW - NATIVE CELLULOSE

U2 - 10.3389/fbioe.2019.00045

DO - 10.3389/fbioe.2019.00045

M3 - Review article

VL - 7

JO - Frontiers in Bioengineering and Biotechnology

JF - Frontiers in Bioengineering and Biotechnology

SN - 2296-4185

IS - MAR

M1 - 45

ER -