Cellular logic with orthogonal ribosomes

Oliver Rackham, Jason W Chin

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The creation and use of unnatural molecules to control cellular function is a long standing goal of the chemical community, but in general, these efforts have been directed at finding molecules to inhibit or activate a particular molecular target or function, or to elicit a particular phenotype. Here we show that multiple unnatural molecules (orthogonal ribosomes) can be used combinatorially, in a single cell, to program Boolean logic functions. These experiments show how attention to the molecular specificity of noncovalent interactions between unnatural macromolecules allows the synthesis of complex function from the "bottom-up" in living matter.

Original languageEnglish
Pages (from-to)17584-5
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number50
DOIs
Publication statusPublished - 21 Dec 2005

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