TY - JOUR
T1 - Cellular and Molecular Mediators of Intestinal Fibrosis
AU - Lawrance, Ian
AU - Rogler, G.
AU - Bamias, G.
AU - Breynaert, C.
AU - Florholmen, J.
AU - Pellino, G.
AU - Reif, S.
AU - Speca, S.
AU - Latella, G.
PY - 2017/12
Y1 - 2017/12
N2 - Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, therefore, a detailed understanding of these pathways is vital to the development of anti-fibrogenic strategies. There have been several recent reviews exploring what is known, and what remains unknown, about the development of intestinal fibrosis. This review is designed to add to this literature but with a focus on the cellular components that are involved in the development of fibrogenesis and the major molecular mediators that impact on these cells. The aim is to heighten the understanding of the factors involved in intestinal fibrogenesis so that detailed research can be encouraged in order to advance the processes that could lead to effective treatments.
AB - Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, therefore, a detailed understanding of these pathways is vital to the development of anti-fibrogenic strategies. There have been several recent reviews exploring what is known, and what remains unknown, about the development of intestinal fibrosis. This review is designed to add to this literature but with a focus on the cellular components that are involved in the development of fibrogenesis and the major molecular mediators that impact on these cells. The aim is to heighten the understanding of the factors involved in intestinal fibrogenesis so that detailed research can be encouraged in order to advance the processes that could lead to effective treatments.
U2 - 10.1016/j.crohns.2014.09.008
DO - 10.1016/j.crohns.2014.09.008
M3 - Article
C2 - 25306501
VL - 11
SP - 1491
EP - 1503
JO - JOURNAL OF CROHNS & COLITIS
JF - JOURNAL OF CROHNS & COLITIS
SN - 1873-9946
IS - 12
ER -