Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Farzaneh Shakeri; Bahram Bibak; Mohammad Reza Safdari; Zakieh Keshavarzi; Tannaz Jamialahmadi; Thozhukat Sathyapalan; Amirhossein Sahebkar

doi:10.2174/0929867329666220210145033

Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

UWA Medical School

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.

Original language	English
Pages (from-to)	2878-2890
Number of pages	13
Journal	Current Medicinal Chemistry
Volume	29
Issue number	16
DOIs	https://doi.org/10.2174/0929867329666220210145033
Publication status	Published - May 2022

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10.2174/0929867329666220210145033

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title = "Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders",

abstract = "There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.",

keywords = "Curcumin, hormones, molecular mechanisms, pituitary gland, thyroid gland, thyrotropin",

author = "Farzaneh Shakeri and Bahram Bibak and Safdari, {Mohammad Reza} and Zakieh Keshavarzi and Tannaz Jamialahmadi and Thozhukat Sathyapalan and Amirhossein Sahebkar",

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AU - Shakeri, Farzaneh

AU - Bibak, Bahram

AU - Safdari, Mohammad Reza

AU - Keshavarzi, Zakieh

AU - Jamialahmadi, Tannaz

AU - Sathyapalan, Thozhukat

AU - Sahebkar, Amirhossein

PY - 2022/5

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N2 - There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.

AB - There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.

KW - Curcumin

KW - hormones

KW - molecular mechanisms

KW - pituitary gland

KW - thyroid gland

KW - thyrotropin

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Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Abstract

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