@article{7c3a0246f711416480252df856d95058,
title = "Cell cycle genes in chondrocyte proliferation and differentiation",
abstract = "Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell cycle proteins play an important role in the coordination of chondrocyte proliferation and differentiation. Our current knowledge of the function and regulation of cell cycle proteins in endochondral ossification is summarized.",
keywords = "Bone growth, Cell cycle, Chondrocytes, Differentiation, Proliferation",
author = "Frank Beier and Leask, {Todd A.} and Shelby Haque and Christopher Chow and Taylor, {Allison C.} and Lee, {Richard J.} and Pestell, {Richard G.} and Ballock, {R. Tracy} and Phyllis Luvalle",
note = "Funding Information: We would like to thank M. Rudnicki for allowing us to discuss some of his unpublished results. Work in our laboratory was supported by grants from the Medical Research Council of Canada, the Alberta Cancer Foundation, and the Arthritis Society to P.L.F.B. was supported by postdoctoral fellowships from Deutscher Akademischer Austauschdienst and Deutsche Forschungsgemeinschaft. S.H. was a recipient of a summer studentship from the Albeta Heritage Foundation for Medical Research. Work in the laboratory of R.G.P. was supported by R29CA70897, RO1 CA75503, P50-HL56399. R.G.P. is a recipient of the Ira T. Hirschl award and an award from the Susan G. Komen Breast Cancer Foundation. Work conducted at the Albert Einstein College of Medicine was supported by Cancer Center Core National Institute of Health grant 5-P30-CA13330-26 and the Mortimer Harrison foundation (R.G.P.). Work from the laboratory of R.T.B. was supported by NIH R29 AR448801, an OREF Career Development Award, and a March of Dimes Basil O'Connor Award. Finally, we express our gratitude to numerous colleagues who supplied us with materials for our studies.",
year = "1999",
month = apr,
day = "1",
doi = "10.1016/S0945-053X(99)00009-8",
language = "English",
volume = "18",
pages = "109--120",
journal = "Matrix Biology",
issn = "0945-053X",
publisher = "Elsevier",
number = "2",
}