CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen

R. Riebke, N. Garbi, Ruth Ganss, G.J. Hammerling, B. Arnold, T. Oelert

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

In comparison with CD4(+) regulatory T cells, the generation and function of immunomodulatory CD8(+) T cells is less well defined. Here we describe the existence of regulatory anti-K-b-Specific CD8(+) T cells that are rendered tolerant during neonatal life via antigen contact exclusively on keratinocytes. These regulatory T cells maintain tolerance during adulthood as they prevent K-b-specific graft rejection by naive CD8(+) T cells. Third-party immune responses remain unaffected. Up-regulation of TGF-beta 1 and granzyme B in the regulatory CD8(+) T cell population suggests the involvement of these molecules in common suppressive pathways shared with CD4(+) regulatory T cells. In summary, CD8(+) regulatory T cells can be induced. extrathymically through antigen contact on neonatally accessible parenchymal cells and maintain tolerance throughout adult life.
Original languageEnglish
Pages (from-to)15142-15147
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number41
DOIs
Publication statusPublished - 2006

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