Cbl: Many adaptations to regulate protein tyrosine kinases

Christine Thien, Wallace Langdon

    Research output: Contribution to journalLiterature review

    528 Citations (Scopus)


    Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

    Original languageEnglish
    Pages (from-to)294-307
    JournalNature Reviews Molecular Cell Biology
    Publication statusPublished - Apr 2001


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