Cbl: Many adaptations to regulate protein tyrosine kinases

Christine Thien; Wallace Langdon

doi:10.1038/35067100

Cbl: Many adaptations to regulate protein tyrosine kinases

Christine Thien, Wallace Langdon

Research output: Contribution to journal › Literature review

528 Citations (Scopus)

Abstract

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

Original language	English
Pages (from-to)	294-307
Journal	Nature Reviews Molecular Cell Biology
Volume	2
DOIs	https://doi.org/10.1038/35067100
Publication status	Published - Apr 2001

Access to Document

10.1038/35067100

Cite this

@article{6aafe420ecef49f6909dc60cac28f962,

title = "Cbl: Many adaptations to regulate protein tyrosine kinases",

abstract = "Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes? ",

author = "Christine Thien and Wallace Langdon",

year = "2001",

month = apr,

doi = "10.1038/35067100",

language = "English",

volume = "2",

pages = "294--307",

journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Cbl: Many adaptations to regulate protein tyrosine kinases

AU - Thien, Christine

AU - Langdon, Wallace

PY - 2001/4

Y1 - 2001/4

N2 - Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

AB - Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

U2 - 10.1038/35067100

DO - 10.1038/35067100

M3 - Literature review

SN - 1471-0072

VL - 2

SP - 294

EP - 307

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

ER -

Cbl: Many adaptations to regulate protein tyrosine kinases

Abstract

Access to Document

Fingerprint

Cite this