Caveolins in cholesterol trafficking and signal transduction: implications for human disease.

A. Schlegel; R. G. Pestell; M. P. Lisanti

doi:10.2741/schlegel

Caveolins in cholesterol trafficking and signal transduction: implications for human disease.

A. Schlegel, R. G. Pestell, M. P. Lisanti

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions.

Original language	English
Pages (from-to)	D929-937
Journal	Frontiers in bioscience : a journal and virtual library
Volume	5
DOIs	https://doi.org/10.2741/schlegel
Publication status	Published - 1 Dec 2000
Externally published	Yes

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10.2741/schlegel

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abstract = "Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions.",

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AU - Lisanti, M. P.

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AB - Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions.

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JO - Frontiers in bioscience : a journal and virtual library

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ER -

Caveolins in cholesterol trafficking and signal transduction: implications for human disease.

Abstract

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