Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

Gerd Ludwig; Goran N. Kaluderovic; Tobias Rueffer; Martin Bette; Marcus Korb; Michael Block; Reinhard Paschke; Heinrich Lang; Dirk Steinborn

doi:10.1039/c3dt33064h

Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

Gerd Ludwig, Goran N. Kaluderovic, Tobias Rueffer, Martin Bette, Marcus Korb, Michael Block, Reinhard Paschke, Heinrich Lang, Dirk Steinborn

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(eta(6)-p-cym)Cl{Ph2P(CH2)(n)S(O)(x)Ph-kappa P,kappa S}][PF6] (n = 1-3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure-activity relationships are discussed.

Original language	English
Pages (from-to)	3771-3774
Number of pages	4
Journal	Dalton Transactions
Volume	42
Issue number	11
DOIs	https://doi.org/10.1039/c3dt33064h
Publication status	Published - 2013
Externally published	Yes

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10.1039/c3dt33064h

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title = "Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents",

abstract = "The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(eta(6)-p-cym)Cl{Ph2P(CH2)(n)S(O)(x)Ph-kappa P,kappa S}][PF6] (n = 1-3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure-activity relationships are discussed.",

keywords = "IN-VITRO, BINDING, CANCER, CYTOTOXICITY, INHIBITION, COMPOUND, TOXICITY, GROWTH, CELLS",

author = "Gerd Ludwig and Kaluderovic, {Goran N.} and Tobias Rueffer and Martin Bette and Marcus Korb and Michael Block and Reinhard Paschke and Heinrich Lang and Dirk Steinborn",

year = "2013",

doi = "10.1039/c3dt33064h",

language = "English",

volume = "42",

pages = "3771--3774",

journal = "Dalton Transactions",

issn = "1477-9226",

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TY - JOUR

T1 - Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

AU - Ludwig, Gerd

AU - Kaluderovic, Goran N.

AU - Rueffer, Tobias

AU - Bette, Martin

AU - Korb, Marcus

AU - Block, Michael

AU - Paschke, Reinhard

AU - Lang, Heinrich

AU - Steinborn, Dirk

PY - 2013

Y1 - 2013

N2 - The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(eta(6)-p-cym)Cl{Ph2P(CH2)(n)S(O)(x)Ph-kappa P,kappa S}][PF6] (n = 1-3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure-activity relationships are discussed.

AB - The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(eta(6)-p-cym)Cl{Ph2P(CH2)(n)S(O)(x)Ph-kappa P,kappa S}][PF6] (n = 1-3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure-activity relationships are discussed.

KW - IN-VITRO

KW - BINDING

KW - CANCER

KW - CYTOTOXICITY

KW - INHIBITION

KW - COMPOUND

KW - TOXICITY

KW - GROWTH

KW - CELLS

U2 - 10.1039/c3dt33064h

DO - 10.1039/c3dt33064h

M3 - Article

SN - 1477-9226

VL - 42

SP - 3771

EP - 3774

JO - Dalton Transactions

JF - Dalton Transactions

IS - 11

ER -

Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

Abstract

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