Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents

Gerd Ludwig, Goran N. Kaluderovic, Tobias Rueffer, Martin Bette, Marcus Korb, Michael Block, Reinhard Paschke, Heinrich Lang, Dirk Steinborn

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Abstract

The synthesis and characterization of cationic ruthenium(II) complexes of the type [Ru(eta(6)-p-cym)Cl{Ph2P(CH2)(n)S(O)(x)Ph-kappa P,kappa S}][PF6] (n = 1-3; x = 0, 1; p-cym = p-cymene) are presented. Furthermore, their high biological potential even against cisplatin-resistant tumor cell lines and their structure-activity relationships are discussed.

Original languageEnglish
Pages (from-to)3771-3774
Number of pages4
JournalDalton Transactions
Volume42
Issue number11
DOIs
Publication statusPublished - 2013
Externally publishedYes

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