Case report: Rapid HIV progression during acute HIV-1 subtype C infection in a Mozambican patient with atypical seroconversion

C. Velasco; Erica Parker; L. Pastor; A. Nhama; S. Macuacua; I.M. Mandomando; J. Blanco; D. Naniche

doi:10.4269/ajtmh.14-0554

Case report: Rapid HIV progression during acute HIV-1 subtype C infection in a Mozambican patient with atypical seroconversion

C. Velasco, Erica Parker, L. Pastor, A. Nhama, S. Macuacua, I.M. Mandomando, J. Blanco, D. Naniche

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. Acute human immunodeficiency virus (HIV) infection (AHI) refers to the period between viral transmission and development of an adaptive immune response to HIV antigens (seroconversion) usually lasting 6-8 weeks. Rare cases have been described in which HIV-infected patients fail to seroconvert and instead, develop rapid HIV-mediated clinical decline. We report the case of a Mozambican woman with AHI and malaria coinfection who showed atypical seroconversion and experienced rapid deterioration and death within 14 weeks of diagnosis with AHI. Atypical seroconversion may be associated with rapid progression. Fourth generation rapid tests could lead to earlier identification and intervention for this vulnerable subgroup.

Original language	English
Pages (from-to)	681-683
Journal	American Journal of Tropical Medicine and Hygiene
Volume	92
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.14-0554
Publication status	Published - 2015

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abstract = "Copyright {\textcopyright} 2015 by The American Society of Tropical Medicine and Hygiene. Acute human immunodeficiency virus (HIV) infection (AHI) refers to the period between viral transmission and development of an adaptive immune response to HIV antigens (seroconversion) usually lasting 6-8 weeks. Rare cases have been described in which HIV-infected patients fail to seroconvert and instead, develop rapid HIV-mediated clinical decline. We report the case of a Mozambican woman with AHI and malaria coinfection who showed atypical seroconversion and experienced rapid deterioration and death within 14 weeks of diagnosis with AHI. Atypical seroconversion may be associated with rapid progression. Fourth generation rapid tests could lead to earlier identification and intervention for this vulnerable subgroup.",

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T1 - Case report: Rapid HIV progression during acute HIV-1 subtype C infection in a Mozambican patient with atypical seroconversion

AU - Velasco, C.

AU - Parker, Erica

AU - Pastor, L.

AU - Nhama, A.

AU - Macuacua, S.

AU - Mandomando, I.M.

AU - Blanco, J.

AU - Naniche, D.

PY - 2015

Y1 - 2015

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AB - Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. Acute human immunodeficiency virus (HIV) infection (AHI) refers to the period between viral transmission and development of an adaptive immune response to HIV antigens (seroconversion) usually lasting 6-8 weeks. Rare cases have been described in which HIV-infected patients fail to seroconvert and instead, develop rapid HIV-mediated clinical decline. We report the case of a Mozambican woman with AHI and malaria coinfection who showed atypical seroconversion and experienced rapid deterioration and death within 14 weeks of diagnosis with AHI. Atypical seroconversion may be associated with rapid progression. Fourth generation rapid tests could lead to earlier identification and intervention for this vulnerable subgroup.

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EP - 683

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 4

ER -

Case report: Rapid HIV progression during acute HIV-1 subtype C infection in a Mozambican patient with atypical seroconversion

Abstract

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