TY - JOUR
T1 - Cardiovascular risk factors in pre-pubertal Malays: Effects of diabetic parentage
AU - Choo, K.E.
AU - Lau, K.B.
AU - Davis, Wendy
AU - Chew, P.H.
AU - Jenkins, A.J.
AU - Davis, Timothy
PY - 2007
Y1 - 2007
N2 - Diabetes prevalence is increasing rapidly in Asian populations but the influence of a family history of diabetes on cardiovascular risk is unknown. To assess this relationship, 120 urban-dwelling Malays were recruited to a cross-sectional case-control study. Sixty were pre-pubertal children, 30 of diabetic parentage (Group 1) and 30 with no diabetes family history (Group 2). Group 1 and 2 subjects were the offspring of adults with (Group 3) or without (Group 4) type 2 diabetes. Subjects were assessed for clinical and biochemical variables defining cardiovascular risk. Principal component analysis assessed clustering of variables in the children. Group I subjects had a higher mean waist:hip ratio, diastolic blood pressure and HbA(1c), than those in Group 2, and a lower HDL:total cholesterol ratio (P < 0.03). Although there were no correlations between Group 1 and 3 subjects for cardiovascular risk variables, significant associations were found in Groups 2 and 4, especially HbA(1c) and insulin sensitivity (P <= 0.004). Of five separate clusters of variables (factors) identified amongst the children, the strongest comprised diabetic parentage, HbA(1c), insulin sensitivity and blood pressure. Features of the metabolic syndrome are becoming evident in the young non-obese children of diabetic Malays, suggesting that lifestyle factors merit particular attention in this group. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
AB - Diabetes prevalence is increasing rapidly in Asian populations but the influence of a family history of diabetes on cardiovascular risk is unknown. To assess this relationship, 120 urban-dwelling Malays were recruited to a cross-sectional case-control study. Sixty were pre-pubertal children, 30 of diabetic parentage (Group 1) and 30 with no diabetes family history (Group 2). Group 1 and 2 subjects were the offspring of adults with (Group 3) or without (Group 4) type 2 diabetes. Subjects were assessed for clinical and biochemical variables defining cardiovascular risk. Principal component analysis assessed clustering of variables in the children. Group I subjects had a higher mean waist:hip ratio, diastolic blood pressure and HbA(1c), than those in Group 2, and a lower HDL:total cholesterol ratio (P < 0.03). Although there were no correlations between Group 1 and 3 subjects for cardiovascular risk variables, significant associations were found in Groups 2 and 4, especially HbA(1c) and insulin sensitivity (P <= 0.004). Of five separate clusters of variables (factors) identified amongst the children, the strongest comprised diabetic parentage, HbA(1c), insulin sensitivity and blood pressure. Features of the metabolic syndrome are becoming evident in the young non-obese children of diabetic Malays, suggesting that lifestyle factors merit particular attention in this group. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
U2 - 10.1016/j.diabres.2006.08.006
DO - 10.1016/j.diabres.2006.08.006
M3 - Article
C2 - 16979774
SN - 0168-8227
VL - 76
SP - 119
EP - 125
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 1
ER -