Cardiovascular risk factors in pre-pubertal Malays: Effects of diabetic parentage

K.E. Choo, K.B. Lau, Wendy Davis, P.H. Chew, A.J. Jenkins, Timothy Davis

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Diabetes prevalence is increasing rapidly in Asian populations but the influence of a family history of diabetes on cardiovascular risk is unknown. To assess this relationship, 120 urban-dwelling Malays were recruited to a cross-sectional case-control study. Sixty were pre-pubertal children, 30 of diabetic parentage (Group 1) and 30 with no diabetes family history (Group 2). Group 1 and 2 subjects were the offspring of adults with (Group 3) or without (Group 4) type 2 diabetes. Subjects were assessed for clinical and biochemical variables defining cardiovascular risk. Principal component analysis assessed clustering of variables in the children. Group I subjects had a higher mean waist:hip ratio, diastolic blood pressure and HbA(1c), than those in Group 2, and a lower HDL:total cholesterol ratio (P < 0.03). Although there were no correlations between Group 1 and 3 subjects for cardiovascular risk variables, significant associations were found in Groups 2 and 4, especially HbA(1c) and insulin sensitivity (P <= 0.004). Of five separate clusters of variables (factors) identified amongst the children, the strongest comprised diabetic parentage, HbA(1c), insulin sensitivity and blood pressure. Features of the metabolic syndrome are becoming evident in the young non-obese children of diabetic Malays, suggesting that lifestyle factors merit particular attention in this group. (c) 2006 Elsevier Ireland Ltd. All fights reserved.
Original languageEnglish
Pages (from-to)119-125
JournalDiabetes Research and Clinical Practice
Volume76
Issue number1
DOIs
Publication statusPublished - 2007

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