Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: Consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient

Vasilios Kotsis, Jens Jordan, Stella Stabouli, Christina Antza, Dragan Micic, Bojan Jelaković, Markus P. Schlaich, Peter M. Nilsson, Reinhold Kreutz, Giuseppe Mancia, Kostas Tsioufis, Guido Grassi

Research output: Contribution to journalArticle

Abstract

The prevalence of type 2 diabetes (T2D) has increased over the past few decades. T2D has a strong genetic propensity that becomes overt when a patient is exposed to a typical Western lifestyle, gain weight and becomes obese, whereas weight loss protects from the development of T2D. Except of lifestyle modifications, the choice of the appropriate treatment is essential in the management of patients with T2D and appears critical for the obese population with T2D. The new pharmacological approach for the treatment of T2D, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists, seems to be effective not only in the management of T2D but also for weight loss, reduction of blood pressure and improvement of nonalcoholic fatty liver disease. Sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 analogues reduced cardiovascular risk, prevented cardiovascular disease and mortality, thereby playing an important role in the treatment of obese patients with hypertension and T2D.

Original languageEnglish
Pages (from-to)377-386
Number of pages10
JournalJournal of Hypertension
Volume38
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020

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