Abstract
PURPOSE OF REVIEW: Pneumonia, an inflammatory disease, is the single largest infectious cause of death. Pneumonia has recently been established as an important contributing factor to major adverse cardiovascular events including heart failure. Developing an intermechanistic understanding of pneumonia and cardiovascular disease is crucial for successful future drug therapy and reducing healthcare expenditure. RECENT FINDINGS: Up to 30% of patients admitted with pneumonia develop cardiovascular complications such as heart failure within 10 years of hospital discharge. Recent mechanistic studies have identified inflammation, pneumolysin, platelet activation, and thrombus formation at the center of cardiovascular disease progression. SUMMARY: In this review, we will detail current knowledge of the mechanistic interaction between pneumonia and development of cardiovascular disease as well as discuss the current and potential drug therapy targets.
| Original language | English |
|---|---|
| Pages (from-to) | 233-239 |
| Number of pages | 7 |
| Journal | Current Opinion in Cardiology |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Mar 2019 |
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Cardiovascular complications following pneumonia : focus on pneumococcus and heart failure. / Bartlett, Benjamin; Ludewick, Herbert P.; Lee, Silvia; Dwivedi, Girish.
In: Current Opinion in Cardiology, Vol. 34, No. 2, 01.03.2019, p. 233-239.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cardiovascular complications following pneumonia
T2 - focus on pneumococcus and heart failure
AU - Bartlett, Benjamin
AU - Ludewick, Herbert P.
AU - Lee, Silvia
AU - Dwivedi, Girish
PY - 2019/3/1
Y1 - 2019/3/1
N2 - PURPOSE OF REVIEW: Pneumonia, an inflammatory disease, is the single largest infectious cause of death. Pneumonia has recently been established as an important contributing factor to major adverse cardiovascular events including heart failure. Developing an intermechanistic understanding of pneumonia and cardiovascular disease is crucial for successful future drug therapy and reducing healthcare expenditure. RECENT FINDINGS: Up to 30% of patients admitted with pneumonia develop cardiovascular complications such as heart failure within 10 years of hospital discharge. Recent mechanistic studies have identified inflammation, pneumolysin, platelet activation, and thrombus formation at the center of cardiovascular disease progression. SUMMARY: In this review, we will detail current knowledge of the mechanistic interaction between pneumonia and development of cardiovascular disease as well as discuss the current and potential drug therapy targets.
AB - PURPOSE OF REVIEW: Pneumonia, an inflammatory disease, is the single largest infectious cause of death. Pneumonia has recently been established as an important contributing factor to major adverse cardiovascular events including heart failure. Developing an intermechanistic understanding of pneumonia and cardiovascular disease is crucial for successful future drug therapy and reducing healthcare expenditure. RECENT FINDINGS: Up to 30% of patients admitted with pneumonia develop cardiovascular complications such as heart failure within 10 years of hospital discharge. Recent mechanistic studies have identified inflammation, pneumolysin, platelet activation, and thrombus formation at the center of cardiovascular disease progression. SUMMARY: In this review, we will detail current knowledge of the mechanistic interaction between pneumonia and development of cardiovascular disease as well as discuss the current and potential drug therapy targets.
UR - http://www.scopus.com/inward/record.url?scp=85061137274&partnerID=8YFLogxK
U2 - 10.1097/HCO.0000000000000604
DO - 10.1097/HCO.0000000000000604
M3 - Article
VL - 34
SP - 233
EP - 239
JO - Current Opinion in Cardiology
JF - Current Opinion in Cardiology
SN - 0268-4705
IS - 2
ER -