Projects per year
Abstract
BACKGROUND: Omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation during infancy may reduce adult cardiovascular risk as observed in animals. We assessed the effect of n-3 LCPUFA supplementation in infancy on growth, body composition, and cardiometabolic risk factors at 5 years of age.
METHODS: Infants were randomly assigned to a daily supplement of n-3 LCPUFA or olive oil (control) from birth to 6 months (n = 420). Measurements included weight, length, cord blood adipokines at birth and anthropometry, skinfolds, blood pressure, heart rate, fasting blood adipokines, and biochemistry at 5 years.
RESULTS: The infants who received n-3 LCPUFA had a smaller waist circumference at 5 years (coefficient: 1.1 cm; 95% confidence interval [CI]: 0.01 to 2.14), which remained significant after adjustments for confounders (coefficient: 0.8 cm; 95% CI: 0.19 to 1.30). Five-year-old boys who received n-3 LCPUFA supplementation as infants had a 21% reduction in insulin concentrations (ratio: 0.79; 95% CI: 0.66 to 0.94) and a 22% reduction in insulin resistance (ratio: 0.78; 95% CI: 0.64 to 0.95) compared with the control group. There were no other differences in growth and cardiometabolic risk factors between the groups for the whole cohort at birth, 2.5, or 5 years.
CONCLUSIONS: Supplementation with n-3 LCPUFA in infancy revealed a reduction in waist circumference at 5 years. Boys in the n-3 LCPUFA group showed reduced insulin concentrations and insulin resistance at 5 years, which may have beneficial outcomes for later health. No effects were seen in girls. Longer term follow-up of the cohort is warranted to determine whether these differences are maintained into adolescence.
Original language | English |
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Pages (from-to) | 1-11 |
Journal | Pediatrics |
Volume | 142 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jul 2018 |
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Dive into the research topics of 'Cardiometabolic Risk Factors at 5 Years After Omega-3 Fatty Acid Supplementation in Infancy'. Together they form a unique fingerprint.Projects
- 3 Finished
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NHMRC Research Fellowships - Trevor Mori
National Health & Medical Research Council NHMRC
1/01/13 → 31/12/17
Project: Research
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Rae-Chi Huang - Early Life Programming of Cardiovascular Disease
Huang, R.
National Health & Medical Research Council NHMRC
1/01/13 → 29/02/20
Project: Research
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The Effects of Fish Oil Supplements & Novel Anti-Inflammatory Metabolites & Telomere Length in Early & Later Life - Potential Implications for Long Term Cardiovascular Risk
Mori, T., Huang, R., Prescott, S., Beilin, L., Fenech, M. & O'Callaghan, N.
National Health & Medical Research Council NHMRC
1/01/11 → 31/12/14
Project: Research