Cardioactive Effects of Eremophila alternifolia Extracts

M. Pennacchio; E. Alexander; Emilio Ghisalberti; G. S. Richmond

doi:10.1016/0378-8741(95)01258-F

Cardioactive Effects of Eremophila alternifolia Extracts

M. Pennacchio, E. Alexander, Emilio Ghisalberti, G. S. Richmond

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart;ate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.

Original language	English
Pages (from-to)	91-95
Journal	Journal of Ethnopharmacology
Volume	47
DOIs	https://doi.org/10.1016/0378-8741(95)01258-F
Publication status	Published - 1995

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title = "Cardioactive Effects of Eremophila alternifolia Extracts",

abstract = "An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart;ate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.",

author = "M. Pennacchio and E. Alexander and Emilio Ghisalberti and Richmond, {G. S.}",

year = "1995",

doi = "10.1016/0378-8741(95)01258-F",

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pages = "91--95",

journal = "Journal of Ethnopharmacology",

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T1 - Cardioactive Effects of Eremophila alternifolia Extracts

AU - Pennacchio, M.

AU - Alexander, E.

AU - Ghisalberti, Emilio

AU - Richmond, G. S.

PY - 1995

Y1 - 1995

N2 - An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart;ate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.

AB - An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart;ate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.

U2 - 10.1016/0378-8741(95)01258-F

DO - 10.1016/0378-8741(95)01258-F

M3 - Article

VL - 47

SP - 91

EP - 95

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

ER -

Cardioactive Effects of Eremophila alternifolia Extracts

Abstract

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