Cardioactive Effects of Eremophila alternifolia Extracts

M. Pennacchio, E. Alexander, Emilio Ghisalberti, G. S. Richmond

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Abstract

An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart;ate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.
Original languageEnglish
Pages (from-to)91-95
JournalJournal of Ethnopharmacology
Volume47
DOIs
Publication statusPublished - 1995

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Pennacchio, M., Alexander, E., Ghisalberti, E., & Richmond, G. S. (1995). Cardioactive Effects of Eremophila alternifolia Extracts. Journal of Ethnopharmacology, 47, 91-95. https://doi.org/10.1016/0378-8741(95)01258-F