An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart;ate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.
Pennacchio, M., Alexander, E., Ghisalberti, E., & Richmond, G. S. (1995). Cardioactive Effects of Eremophila alternifolia Extracts. Journal of Ethnopharmacology, 47, 91-95. https://doi.org/10.1016/0378-8741(95)01258-F