TY - JOUR
T1 - Cardioactive compounds from Eremophila species
AU - Pennacchio, M.
AU - Syah, Y.M.
AU - Ghisalberti, Emilio
AU - Alexander, E.
PY - 1996
Y1 - 1996
N2 - The isolation and identification of two cardioactive compounds from two Eremophila species (Myoporaceae) considered important in the pharmacopoeia of the Australian Aboriginal people is described. Verbascoside, isolated from the methanol and water extracts of E. alternifolia leaves, mediated significant increases in chronotropism, inotropism and coronary perfusion rate (CPR) in the Langendorff rat heart. Geniposidic acid, isolated from the methanol extract of E. longifolia leaves, mediated an inhibitory effect with significant negative chronotropism, negative inotropism and CPR.
AB - The isolation and identification of two cardioactive compounds from two Eremophila species (Myoporaceae) considered important in the pharmacopoeia of the Australian Aboriginal people is described. Verbascoside, isolated from the methanol and water extracts of E. alternifolia leaves, mediated significant increases in chronotropism, inotropism and coronary perfusion rate (CPR) in the Langendorff rat heart. Geniposidic acid, isolated from the methanol extract of E. longifolia leaves, mediated an inhibitory effect with significant negative chronotropism, negative inotropism and CPR.
U2 - 10.1016/0378-8741(96)01422-5
DO - 10.1016/0378-8741(96)01422-5
M3 - Article
VL - 53
SP - 21
EP - 27
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
ER -