TY - JOUR
T1 - Cardiac Transplantation in HIV-Positive Patients
T2 - A Narrative Review
AU - Wairimu, Faith
AU - Ward, Natalie C.
AU - Liu, Yingwei
AU - Dwivedi, Girish
PY - 2021/6/1
Y1 - 2021/6/1
N2 - ABSTRACT: Before the introduction of highly active antiretroviral therapy, patients infected with HIV experienced poor prognosis including high rates of opportunistic infections, rapid progression to AIDS, and significant mortality. Increased life expectancy after therapeutic improvements has led to an increase in other chronic diseases for these patients, including cardiovascular disease and, in particular, end-stage heart failure. Historically, HIV infection was deemed an absolute contraindication for transplantation. Since the development of highly active antiretroviral therapy, however, life expectancy for HIV-positive patients has significantly improved. In addition, there is a low incidence of opportunistic infections and the current antiretrovirals have an improved toxicity profile. Despite this, the current status of cardiac transplants in HIV-positive patients remains unclear. With this in mind, we conducted a narrative review on cardiac transplantation in patients with HIV.
AB - ABSTRACT: Before the introduction of highly active antiretroviral therapy, patients infected with HIV experienced poor prognosis including high rates of opportunistic infections, rapid progression to AIDS, and significant mortality. Increased life expectancy after therapeutic improvements has led to an increase in other chronic diseases for these patients, including cardiovascular disease and, in particular, end-stage heart failure. Historically, HIV infection was deemed an absolute contraindication for transplantation. Since the development of highly active antiretroviral therapy, however, life expectancy for HIV-positive patients has significantly improved. In addition, there is a low incidence of opportunistic infections and the current antiretrovirals have an improved toxicity profile. Despite this, the current status of cardiac transplants in HIV-positive patients remains unclear. With this in mind, we conducted a narrative review on cardiac transplantation in patients with HIV.
UR - http://www.scopus.com/inward/record.url?scp=85106667047&partnerID=8YFLogxK
U2 - 10.1097/QAI.0000000000002647
DO - 10.1097/QAI.0000000000002647
M3 - Review article
C2 - 33534274
AN - SCOPUS:85106667047
SN - 1525-4135
VL - 87
SP - 763
EP - 768
JO - Journal of acquired immune deficiency syndromes (1999)
JF - Journal of acquired immune deficiency syndromes (1999)
IS - 2
ER -
