Cannabis genotoxicity and cancer incidence: Highly concordant synthesis of European and USA datasets

The reports of the epidemiologically causal involvement of cannabis in incident and inheritable carcinogenesis in the USA, along with the explicated epidemiology of cannabis and cancer in Europe, provide the opportunity to compare the experience of the two continents. Twenty-eight cancers in the USA and 41 cancers in Europe were studied epidemiologically. Bivariate regression of the cancer rates of each region against metrics of cannabis exposure revealed almost complete overlap between the positive findings in the two datasets with 100% of 23 USA cannabis-related cancers and 25/27 (95.6%) European cannabis-related cancers being confirmed where data permitted comparison. P-values ranged to 2.20×10−307, E-value estimates ranged to 6.09×1042, and minimum E-values descended from 1.01×1030. Exponential genotoxic dose-response relationships are most concerning at higher dosages and caution strongly against widespread exposure to cannabinoids including food chain contamination. In total, 1754 megabases (59%) of the human genome are directly impacted by cannabinoid genotoxicity. Remarkable concordance between transatlantic datasets, which together comprise the majority of the publicly available global data, indicates that transgenerational cannabinoid-related mutagenicity-carcinogenicity is an important population health issue.