Cancer incidence in the Western Australian mining industry (1996–2013)

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Abstract

Background Miners are frequently exposed to established and potential carcinogens. We aimed to assess cancer incidence in miners relative to the general population and identify high-risk subgroups. Methods Incident cancers in Western Australian miners (n = 153,922; 86% male) during 1996–2013 were identified. Indirectly standardised incidence ratios (SIRs) were calculated and mixed-effects Poisson models were used to calculate Incidence Rate Ratios (IRRs) to identify high-risk within-cohort subgroups. Results Compared with the general population, the overall cancer incidence in miners (n = 4194 cases) was lower for both females (SIR:0.83, 95%CI:0.74–0.92) and males (SIR:0.96, 95%CI:0.93–0.99). Overall, cancer incidence did not differ by employment duration or employment commencement time. Ever-underground work was associated with lung cancer (IRR:1.81, 95%CI:1.11–2.93). Relative to multi-ore miners, IRRs for specific cancers were significantly different when exclusively mining: iron (prostate:0.73, 95%CI:0.56–0.94); gold (lung:1.77, 95%CI:1.04–3.01 and colorectum:1.70, 95%CI:1.16–2.51); and other metals (urinary tract:1.85, 95%CI:1.03–3.31 and leukaemia:0.36, 95%CI:0.14–0.96). Conclusion Working underground emerged as a significant determinant of lung cancer risk in our contemporary mining cohort. Increased risks of lung, prostate, colorectal and urinary tract cancers and leukaemia were identified in miners of specific ores. These findings underline the importance of continued surveillance of the health and exposures of this relatively young cohort of miners.

Original languageEnglish
Pages (from-to)8-18
Number of pages11
JournalCancer Epidemiology
Volume49
DOIs
Publication statusPublished - 1 Aug 2017

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Industry
Incidence
Neoplasms
Prostate
Lung Neoplasms
Leukemia
Urologic Neoplasms
Lung
Miners
Urinary Tract
Gold
Carcinogens
Population
Iron
Metals
Health

Cite this

@article{ad687ac9cd344663a5f2c5eccfeedc14,
title = "Cancer incidence in the Western Australian mining industry (1996–2013)",
abstract = "Background Miners are frequently exposed to established and potential carcinogens. We aimed to assess cancer incidence in miners relative to the general population and identify high-risk subgroups. Methods Incident cancers in Western Australian miners (n = 153,922; 86{\%} male) during 1996–2013 were identified. Indirectly standardised incidence ratios (SIRs) were calculated and mixed-effects Poisson models were used to calculate Incidence Rate Ratios (IRRs) to identify high-risk within-cohort subgroups. Results Compared with the general population, the overall cancer incidence in miners (n = 4194 cases) was lower for both females (SIR:0.83, 95{\%}CI:0.74–0.92) and males (SIR:0.96, 95{\%}CI:0.93–0.99). Overall, cancer incidence did not differ by employment duration or employment commencement time. Ever-underground work was associated with lung cancer (IRR:1.81, 95{\%}CI:1.11–2.93). Relative to multi-ore miners, IRRs for specific cancers were significantly different when exclusively mining: iron (prostate:0.73, 95{\%}CI:0.56–0.94); gold (lung:1.77, 95{\%}CI:1.04–3.01 and colorectum:1.70, 95{\%}CI:1.16–2.51); and other metals (urinary tract:1.85, 95{\%}CI:1.03–3.31 and leukaemia:0.36, 95{\%}CI:0.14–0.96). Conclusion Working underground emerged as a significant determinant of lung cancer risk in our contemporary mining cohort. Increased risks of lung, prostate, colorectal and urinary tract cancers and leukaemia were identified in miners of specific ores. These findings underline the importance of continued surveillance of the health and exposures of this relatively young cohort of miners.",
keywords = "Cancer incidence, Miners, Occupational cohort, Smoking, Underground mining",
author = "Nita Sodhi-Berry and Alison Reid and Lin Fritschi and Musk, {AW (Bill)} and Roel Vermeulen and {de Klerk}, Nicholas and Susan Peters",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.canep.2017.05.001",
language = "English",
volume = "49",
pages = "8--18",
journal = "Cancer Detection and Prevention",
issn = "0361-090X",
publisher = "Elsevier",

}

Cancer incidence in the Western Australian mining industry (1996–2013). / Sodhi-Berry, Nita; Reid, Alison; Fritschi, Lin; Musk, AW (Bill); Vermeulen, Roel; de Klerk, Nicholas; Peters, Susan.

In: Cancer Epidemiology, Vol. 49, 01.08.2017, p. 8-18.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cancer incidence in the Western Australian mining industry (1996–2013)

AU - Sodhi-Berry, Nita

AU - Reid, Alison

AU - Fritschi, Lin

AU - Musk, AW (Bill)

AU - Vermeulen, Roel

AU - de Klerk, Nicholas

AU - Peters, Susan

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background Miners are frequently exposed to established and potential carcinogens. We aimed to assess cancer incidence in miners relative to the general population and identify high-risk subgroups. Methods Incident cancers in Western Australian miners (n = 153,922; 86% male) during 1996–2013 were identified. Indirectly standardised incidence ratios (SIRs) were calculated and mixed-effects Poisson models were used to calculate Incidence Rate Ratios (IRRs) to identify high-risk within-cohort subgroups. Results Compared with the general population, the overall cancer incidence in miners (n = 4194 cases) was lower for both females (SIR:0.83, 95%CI:0.74–0.92) and males (SIR:0.96, 95%CI:0.93–0.99). Overall, cancer incidence did not differ by employment duration or employment commencement time. Ever-underground work was associated with lung cancer (IRR:1.81, 95%CI:1.11–2.93). Relative to multi-ore miners, IRRs for specific cancers were significantly different when exclusively mining: iron (prostate:0.73, 95%CI:0.56–0.94); gold (lung:1.77, 95%CI:1.04–3.01 and colorectum:1.70, 95%CI:1.16–2.51); and other metals (urinary tract:1.85, 95%CI:1.03–3.31 and leukaemia:0.36, 95%CI:0.14–0.96). Conclusion Working underground emerged as a significant determinant of lung cancer risk in our contemporary mining cohort. Increased risks of lung, prostate, colorectal and urinary tract cancers and leukaemia were identified in miners of specific ores. These findings underline the importance of continued surveillance of the health and exposures of this relatively young cohort of miners.

AB - Background Miners are frequently exposed to established and potential carcinogens. We aimed to assess cancer incidence in miners relative to the general population and identify high-risk subgroups. Methods Incident cancers in Western Australian miners (n = 153,922; 86% male) during 1996–2013 were identified. Indirectly standardised incidence ratios (SIRs) were calculated and mixed-effects Poisson models were used to calculate Incidence Rate Ratios (IRRs) to identify high-risk within-cohort subgroups. Results Compared with the general population, the overall cancer incidence in miners (n = 4194 cases) was lower for both females (SIR:0.83, 95%CI:0.74–0.92) and males (SIR:0.96, 95%CI:0.93–0.99). Overall, cancer incidence did not differ by employment duration or employment commencement time. Ever-underground work was associated with lung cancer (IRR:1.81, 95%CI:1.11–2.93). Relative to multi-ore miners, IRRs for specific cancers were significantly different when exclusively mining: iron (prostate:0.73, 95%CI:0.56–0.94); gold (lung:1.77, 95%CI:1.04–3.01 and colorectum:1.70, 95%CI:1.16–2.51); and other metals (urinary tract:1.85, 95%CI:1.03–3.31 and leukaemia:0.36, 95%CI:0.14–0.96). Conclusion Working underground emerged as a significant determinant of lung cancer risk in our contemporary mining cohort. Increased risks of lung, prostate, colorectal and urinary tract cancers and leukaemia were identified in miners of specific ores. These findings underline the importance of continued surveillance of the health and exposures of this relatively young cohort of miners.

KW - Cancer incidence

KW - Miners

KW - Occupational cohort

KW - Smoking

KW - Underground mining

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U2 - 10.1016/j.canep.2017.05.001

DO - 10.1016/j.canep.2017.05.001

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EP - 18

JO - Cancer Detection and Prevention

JF - Cancer Detection and Prevention

SN - 0361-090X

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