Cancer development in patients hospitalised with systemic lupus erythematosus: A longitudinal population-level data linkage study

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Abstract

Background The association between systemic lupus erythematosus (SLE) and cancer risk is unclear.Objectives Describe the association between systemic lupus erythematosus (SLE) and the risk of cancer development and subsequent 5-year mortality in Western Australia (WA).Methods Population-level cohort study of SLE patients (n=2,111) and general population comparators (n=21,110) hospitalised between 1980–2014. SLE patients (identified by ICD-9-CM: 695.4, 710.0, and ICD-10-AM: L93.0, M32.0) were nearest matched (10:1) for age, sex, Aboriginality, and temporality. Follow-up was from timezero (index SLE hospitalisation) to cancer development, death or 31/12/2014. Using longitudinal linked health data, we determined the risk of cancer development and subsequent 5-year mortality between SLE patients and comparators with Cox proportional hazards regression models.Results SLE patients had similar multivariate-adjusted risk (aHR 1.03, 95%CI 0.93, 1.15; P=0.583) of cancer development. Cancer development risk was higher in SLE patients
Original languageEnglish
Pages (from-to)671-671
Number of pages1
JournalAnnals of the Rheumatic Diseases
Volume81
DOIs
Publication statusPublished - Jun 2022

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