Fragmented human bone collected from the Camposanto cemetery on the Quarantine island of Lazzaretto Nuovo were assessed using the Mack et al (2016) landmark method. Part I provides ahistorical background including an abridged history of Venice and its population. Part II focuses on the analysis of fragments, including MNE and MNI counts. A total of 7,330 fragments result in a MNI=24 estimate. Part III explores whether the Camposanto cemetery can be considered a plague grave, assesses the applicability of the landmark method for assessing fragments, and reviews the significance of the MNI and age demographics within the historical context.