Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity

Estabelle Ang; Nathan Pavlos; L.Y. Chai; M. Qi; Tak Sum Cheng; Jay Steer; David Joyce; Ming Zheng; Jiake Xu

doi:10.1002/jcp.21898

Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity

Estabelle Ang, Nathan Pavlos, L.Y. Chai, M. Qi, Tak Sum Cheng, Jay Steer, David Joyce, Ming Zheng, Jiake Xu

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Receptor activator NF-kB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acidphenethyl ester (CAPE), a natural NF-kB inhibitor from honeybee propolis has been shown to have anti-tumor and anti-inflammatoryproperties. In this study, we investigated the effect of CAPE on the regulation of RANKL-induced osteoclastogenesis, bone resorption andsignaling pathways. Low concentrations of CAPE (

Original language	English
Pages (from-to)	642-649
Journal	Journal of Cellular Physiology
Volume	221
Issue number	3
DOIs	https://doi.org/10.1002/jcp.21898
Publication status	Published - 2009

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10.1002/jcp.21898

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Ang, E., Pavlos, N., Chai, L. Y., Qi, M., Cheng, T. S., Steer, J., Joyce, D., Zheng, M., & Xu, J. (2009). Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity. Journal of Cellular Physiology, 221(3), 642-649. https://doi.org/10.1002/jcp.21898

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title = "Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity",

abstract = "Receptor activator NF-kB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acidphenethyl ester (CAPE), a natural NF-kB inhibitor from honeybee propolis has been shown to have anti-tumor and anti-inflammatoryproperties. In this study, we investigated the effect of CAPE on the regulation of RANKL-induced osteoclastogenesis, bone resorption andsignaling pathways. Low concentrations of CAPE (",

author = "Estabelle Ang and Nathan Pavlos and L.Y. Chai and M. Qi and Cheng, {Tak Sum} and Jay Steer and David Joyce and Ming Zheng and Jiake Xu",

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doi = "10.1002/jcp.21898",

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pages = "642--649",

journal = "Journal of Cellular Physiology",

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Ang, E, Pavlos, N, Chai, LY, Qi, M, Cheng, TS , Steer, J , Joyce, D , Zheng, M & Xu, J 2009, 'Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity', Journal of Cellular Physiology, vol. 221, no. 3, pp. 642-649. https://doi.org/10.1002/jcp.21898

Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity. / Ang, Estabelle; Pavlos, Nathan; Chai, L.Y. et al.
In: Journal of Cellular Physiology, Vol. 221, No. 3, 2009, p. 642-649.

Research output: Contribution to journal › Article › peer-review

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AU - Cheng, Tak Sum

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AU - Zheng, Ming

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AB - Receptor activator NF-kB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acidphenethyl ester (CAPE), a natural NF-kB inhibitor from honeybee propolis has been shown to have anti-tumor and anti-inflammatoryproperties. In this study, we investigated the effect of CAPE on the regulation of RANKL-induced osteoclastogenesis, bone resorption andsignaling pathways. Low concentrations of CAPE (

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Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity

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