Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kB and NFAT activity

Estabelle Ang, Nathan Pavlos, L.Y. Chai, M. Qi, Tak Sum Cheng, Jay Steer, David Joyce, Ming Zheng, Jiake Xu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Receptor activator NF-kB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acidphenethyl ester (CAPE), a natural NF-kB inhibitor from honeybee propolis has been shown to have anti-tumor and anti-inflammatoryproperties. In this study, we investigated the effect of CAPE on the regulation of RANKL-induced osteoclastogenesis, bone resorption andsignaling pathways. Low concentrations of CAPE (
Original languageEnglish
Pages (from-to)642-649
JournalJournal of Cellular Physiology
Volume221
Issue number3
DOIs
Publication statusPublished - 2009

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