Abstract
Receptor activator NF-kB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acidphenethyl ester (CAPE), a natural NF-kB inhibitor from honeybee propolis has been shown to have anti-tumor and anti-inflammatoryproperties. In this study, we investigated the effect of CAPE on the regulation of RANKL-induced osteoclastogenesis, bone resorption andsignaling pathways. Low concentrations of CAPE (
Original language | English |
---|---|
Pages (from-to) | 642-649 |
Journal | Journal of Cellular Physiology |
Volume | 221 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2009 |