Burkitt lymphoma of the oral cavity: an atypical presentation

Ramesh Balasubramaniam, L.N. Turner, E.T. Stoopler, F. Alawi, D.M. Frank, M.S. Greenberg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Burkitt lymphoma (BL) is an aggressive form of non-Hodgkin B-cell lymphoma with 3 variants: endemic,sporadic, and immunodeficiency-associated types. The sporadic form, most commonly involving the abdomen andileocecal region, presents as an abdominal mass, rarely presenting in the orofacial region. A 36-year-old Indian femalepresented to the Hospital of the University of Pennsylvania for evaluation of a persistent intraoral swelling ulcerationof the lower right mandibular alveolar ridge with minimal bony invasion. Progressive systemic symptoms of fatigue,weakness, and fever developed without resolution following treatment for a presumed odontogenic infection in the 4weeks before presentation. An incisional biopsy revealed a diffuse proliferation of intermediate- to large-sizedlymphocytes with multiple small peripheral nucleoli, scant cytoplasm, and nuclear pleomorphism. Nearly all cellsdisplayed Ki67 expression. A final diagnosis of BL was rendered following confirmation of a cMYC translocation byfluorescence in situ hybridization. This article presents a case of the sporadic form of BL with atypical presentationclinically and morphologically, primarily involving the oral soft tissue.
Original languageEnglish
Pages (from-to)240-245
JournalORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY, AND ENDODONTOLOGY
Volume107
Issue number2
DOIs
Publication statusPublished - 2009

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