Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil

D.B. Rolim, D.C.F.L. Vilar, L.P. De Goes Cavalcanti, C.L.B.N. Freitas, Tim Inglis, J.L.N. Nobre Rodrigues, A.T. Nagao-Dias

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    Abstract

    A seroepidemiological investigation was conducted among the population of two municipalities in Northeastern Brazil. Immunoglobulin M (IgM) and IgG antibodies to Burkholderia pseudomallei were positive in 51.27% (161 in 317 samples) and 58.49% (186), respectively. IgM titers were higher in children than in adults. On the contrary, IgG increased progressively with age. We observed a significant association between agricultural occupation and raised IgM titers (P <0.005) and IgG titers (P <0.001), and between construction workers and raised IgG titers (P = 0.005). Antibody IgG avidities did not correlate with age. The highest titers of antibodies (1/800) showed the highest antibody avidity indexes (P <0.01). Most of the serum samples recognized 45-kDa and 200-kDa bands by IgG1 and IgG2 subclasses. Our study showed a high seropositivity among individuals living in endemic regions of the state of Ceara, and highlights the need for further surveillance close to water courses such as dams and rivers in Northeastern Brazil.
    Original languageEnglish
    Pages (from-to)302-305
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume84
    DOIs
    Publication statusPublished - 2011

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    Burkholderia pseudomallei
    Brazil
    Immunoglobulin G
    Antibodies
    Immunoglobulin M
    Antibody Affinity
    Occupations
    Rivers
    Water
    Serum

    Cite this

    Rolim, D. B., Vilar, D. C. F. L., De Goes Cavalcanti, L. P., Freitas, C. L. B. N., Inglis, T., Nobre Rodrigues, J. L. N., & Nagao-Dias, A. T. (2011). Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil. American Journal of Tropical Medicine and Hygiene, 84, 302-305. https://doi.org/10.4269/ajtmh.2011.10-0220
    Rolim, D.B. ; Vilar, D.C.F.L. ; De Goes Cavalcanti, L.P. ; Freitas, C.L.B.N. ; Inglis, Tim ; Nobre Rodrigues, J.L.N. ; Nagao-Dias, A.T. / Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil. In: American Journal of Tropical Medicine and Hygiene. 2011 ; Vol. 84. pp. 302-305.
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    abstract = "A seroepidemiological investigation was conducted among the population of two municipalities in Northeastern Brazil. Immunoglobulin M (IgM) and IgG antibodies to Burkholderia pseudomallei were positive in 51.27{\%} (161 in 317 samples) and 58.49{\%} (186), respectively. IgM titers were higher in children than in adults. On the contrary, IgG increased progressively with age. We observed a significant association between agricultural occupation and raised IgM titers (P <0.005) and IgG titers (P <0.001), and between construction workers and raised IgG titers (P = 0.005). Antibody IgG avidities did not correlate with age. The highest titers of antibodies (1/800) showed the highest antibody avidity indexes (P <0.01). Most of the serum samples recognized 45-kDa and 200-kDa bands by IgG1 and IgG2 subclasses. Our study showed a high seropositivity among individuals living in endemic regions of the state of Ceara, and highlights the need for further surveillance close to water courses such as dams and rivers in Northeastern Brazil.",
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    Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil. / Rolim, D.B.; Vilar, D.C.F.L.; De Goes Cavalcanti, L.P.; Freitas, C.L.B.N.; Inglis, Tim; Nobre Rodrigues, J.L.N.; Nagao-Dias, A.T.

    In: American Journal of Tropical Medicine and Hygiene, Vol. 84, 2011, p. 302-305.

    Research output: Contribution to journalArticle

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    T1 - Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil

    AU - Rolim, D.B.

    AU - Vilar, D.C.F.L.

    AU - De Goes Cavalcanti, L.P.

    AU - Freitas, C.L.B.N.

    AU - Inglis, Tim

    AU - Nobre Rodrigues, J.L.N.

    AU - Nagao-Dias, A.T.

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    AB - A seroepidemiological investigation was conducted among the population of two municipalities in Northeastern Brazil. Immunoglobulin M (IgM) and IgG antibodies to Burkholderia pseudomallei were positive in 51.27% (161 in 317 samples) and 58.49% (186), respectively. IgM titers were higher in children than in adults. On the contrary, IgG increased progressively with age. We observed a significant association between agricultural occupation and raised IgM titers (P <0.005) and IgG titers (P <0.001), and between construction workers and raised IgG titers (P = 0.005). Antibody IgG avidities did not correlate with age. The highest titers of antibodies (1/800) showed the highest antibody avidity indexes (P <0.01). Most of the serum samples recognized 45-kDa and 200-kDa bands by IgG1 and IgG2 subclasses. Our study showed a high seropositivity among individuals living in endemic regions of the state of Ceara, and highlights the need for further surveillance close to water courses such as dams and rivers in Northeastern Brazil.

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