Burkholderia pseudomallei: animal models of infection

R.W. W. Titball, P. Russell, J. Cuccui, A. Easton, A. Haque, T. Atkins, Mitali Sarkar-Tyson, V. Harley, B. Wren, G.J. J. Bancroft

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Summary: A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in some cases, an apparently latent infection to an acute fulminant disease. Alternative small animal models of infection include diabetic rats or hamsters. Larger animal models of disease have not yet been fully developed. It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans. However, the findings that diabetic rats are susceptible to infection, that some strains of mice can develop persistent subclinical infections that can spontaneously reactivate, and that inhalation exposure generally results in more acute disease suggest that these different models mimic different aspects of human melioidosis. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)S111-S116
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume102
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2008

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