Bullous Variant of Central Serous Chorioretinopathy Expansion of Phenotypic Features Using Multimethod Imaging

Chandrakumar Balaratnasingam, K.B. Freund, A.M. Tan, S. Mrejen, A.P. Hunyor, D.J. Keegan, K.K. Dansingani, P.N. Dayani, I.A. Barbazetto, D. Sarraf, L.M. Jampol, L.A. Yannuzzi

Research output: Chapter in Book/Conference paperConference paperpeer-review

49 Citations (Scopus)

Abstract

© 2016 American Academy of Ophthalmology.Purpose To define the phenotypic characteristics of the bullous variant of central serous chorioretinopathy (CSC) using multimethod imaging. Design Retrospective, observational case series. Participants Twenty-one eyes of 14 patients with bullous retinal detachment resulting from CSC (bullous CSC group) and 122 eyes of 84 patients with chronic CSC without bullous retinal detachment (nonbullous CSC group). Methods We performed a retrospective review of clinical and multimethod imaging data of patients who sought treatment from the authors with bullous retinal detachment resulting from CSC between January 2010 and November 2015. Multimethod imaging comprised color photography, fluorescein angiography, fundus autofluorescence, and high-resolution optical coherence tomography. Consecutive cases of chronic CSC without bullous retinal detachment, seen during the same period, comprised a comparative group. Main Outcome Measures Qualitative and quantitative characteristics of the choroid, retinal pigment epithelium, and retina were compared between the 2 groups. Results Mean age of the bullous CSC group was 53.8 years. There was no difference in age, visual acuity, corticosteroid use, or the proportion of white patients and men between the 2 groups (all P > 0.132). Peripheral nonperfusion occurred only in eyes with bullous retinal detachment (38% of cases). Retinal pigment epithelial tears were seen in 95% of eyes in the bullous group and none of the eyes in the nonbullous CSC group. The bullous CSC group demonstrated a greater number of pigment epithelial detachments (PEDs) and more eyes demonstrated PEDs with internal hyperreflectivity (both P <0.016). Mean subfoveal choroidal thickness in the bullous CSC group (463.1±83.1 µm) was not different compared with that of the nonbullous CSC group (400.6±100.6 µm; P = 0.993). More eyes in the bullous CSC group demonstrated hyperreflectivity around large choroidal vessels and at the level of the choriocapillaris on OCT (P <0.001). Ret
Original languageEnglish
Title of host publicationOphthalmology
EditorsMark Titherington
PublisherElsevier
Pages1541-1552
Number of pages12
Volume123
Edition7
ISBN (Print)01616420
DOIs
Publication statusPublished - 1 Jul 2016
EventMacula 2016 and The 40th Annual Meeting of the Atlantic Coast Retina Club - New York, New York, United States
Duration: 8 Jan 20169 Jan 2016

Publication series

NameOphthalmology
ISSN (Print)0161-6420

Workshop

WorkshopMacula 2016 and The 40th Annual Meeting of the Atlantic Coast Retina Club
Country/TerritoryUnited States
CityNew York, New York
Period8/01/169/01/16

Fingerprint

Dive into the research topics of 'Bullous Variant of Central Serous Chorioretinopathy Expansion of Phenotypic Features Using Multimethod Imaging'. Together they form a unique fingerprint.

Cite this