Bronchial mucus transport velocity in patients receiving Propofol and Remifentanil versus Sevoflurane and Remifentanil anesthesia

Thomas Ledowski, Mike Paech, B. Patel, Stephan Schug

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    Volatile anesthetics reduce ciliary beat frequency in vitro. It has been reported that impaired bronchial mucus transport velocity (BTV) is associated with significantly increased pulmonary complications. In this study, we sought to determine in vivo differences in BTV, comparing patients having total IV anesthesia (TIVA) with propofol and remifentanil to anesthesia with sevoflurane and remifentanil. Twenty-two patients scheduled for elective general surgery were randomized to one of two groups: TIVA (propofol/ remifentanil) or SEVO (sevoflurane/remifentanil). Thirty minutes after tracheal intubation, BTV was assessed by fiberoptic observation of the movement of methylene blue dye applied to the dorsal surface of the right main bronchus. BTV was significantly reduced in the SEVO group compared with the TIVA group (mean, 1.5 +/- 0.7 [0-2.3] versus 4.8 +/- 2.1 [2.3-8.8] mm/min; P < 0.0001). Anesthesia with sevoflurane may lead to significantly impaired bronchociliary clearance in comparison to TIVA. This could have implications for perioperative pulmonary complications, in particular in patients at risk for pulmonary complications.
    Original languageEnglish
    Pages (from-to)1427-1430
    JournalAnesthesia and Analgesia
    Volume102
    Issue number5
    DOIs
    Publication statusPublished - 2006

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