Bridging innate and adaptive immunity through genomics: Insights into host variation and immune response across disease contexts

Eric Alves

doi:10.26182/qxcp-fc75

Bridging innate and adaptive immunity through genomics: Insights into host variation and immune response across disease contexts

Eric Alves

Research output: Thesis › Doctoral Thesis

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Gaudieri, Silvana, Supervisor Blancafort, Pilar, Supervisor Choi, Yu Suk, Supervisor Waryah, Charlene, Supervisor Currenti, Jennifer, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	4 Sept 2025
DOIs	https://doi.org/10.26182/qxcp-fc75
Publication status	Published - 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Embargo information

Embargoed from 04/09/2025 to 01/09/2027. Will be made publicly available on 01/09/2027.

Access to Document

10.26182/qxcp-fc75

Embargoed Document

THESIS - DOCTOR OF PHILOSOPHY - ALVES Eric Ian - 2025
64.6 MB
Embargo ends: 1/09/27

HIV-1 adapts to HLA class II–associated selection pressure exerted by CD4⁺ and CD8⁺ T cells
Alves, E., Currenti, J., Crawford, K., Chopra, A., Ram, R., Barnett, L., Read, J. F., Al-Kaabi, M., James, I., Carlson, J. M., Eton, M., Stelmach, S., Deshpande, P., Pilkinton, M. A., McDonnell, W. J., Bosco, A., Mallal, S. A., John, M., Kalams, S. A. & Gaudieri, S., Feb 2025, In: Science Advances. 11, 7, 17 p., eadr4238.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Link opens in a new tab Citation (Scopus)
Underrepresentation of activating KIR gene expression in single-cell RNA-seq data is due to KIR gene misassignment
Alves, E., Chopra, A., Ram, R., Currenti, J., Kalams, S. A., Mallal, S. A., Phillips, E. J. & Gaudieri, S., Jan 2024, In: European Journal of Immunology. 54, 1, 4 p., 2350590.
Research output: Contribution to journal › Article › peer-review

Open Access

2 Link opens in a new tab Citations (Scopus)
Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains
Alves, E., Al-Kaabi, M., Keane, N. M., Leary, S., Almeida, C. A. M., Deshpande, P., Currenti, J., Chopra, A., Smith, R., Castley, A., Mallal, S., Kalams, S. A., Gaudieri, S. & John, M., Dec 2022, In: PLoS Pathogens. 18, 12, e1010965.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Link opens in a new tab Citations (Scopus)

Cite this

@phdthesis{67537f85b0fa49768d0e13f7f3d9df5e,

title = "Bridging innate and adaptive immunity through genomics: Insights into host variation and immune response across disease contexts",

keywords = "immunogenetics, T cells, NK cells, HIV, breast cancer, influenza, human leukocyte antigen (HLA)",

author = "Eric Alves",

year = "2025",

doi = "10.26182/qxcp-fc75",

language = "English",

school = "The University of Western Australia",

}

TY - BOOK

T1 - Bridging innate and adaptive immunity through genomics: Insights into host variation and immune response across disease contexts

AU - Alves, Eric

PY - 2025

Y1 - 2025

KW - immunogenetics

KW - T cells

KW - NK cells

KW - HIV

KW - breast cancer

KW - influenza

KW - human leukocyte antigen (HLA)

U2 - 10.26182/qxcp-fc75

DO - 10.26182/qxcp-fc75

M3 - Doctoral Thesis

ER -

Bridging innate and adaptive immunity through genomics: Insights into host variation and immune response across disease contexts

UN SDGs

Embargo information

Access to Document

Embargoed Document

Research output

HIV-1 adapts to HLA class II–associated selection pressure exerted by CD4+ and CD8+ T cells

Underrepresentation of activating KIR gene expression in single-cell RNA-seq data is due to KIR gene misassignment

Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains

Cite this

HIV-1 adapts to HLA class II–associated selection pressure exerted by CD4⁺ and CD8⁺ T cells