Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors

Kathryn Greenop, Helen Bailey, M.R. Miller, R.J. Scott, J.R. Attia, L.J. Ashton, P. Downie, B.K. Armstrong, Elizabeth Milne

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Abstract

© 2015 Taylor & Francis Group, LLC. Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.
Original languageEnglish
Pages (from-to)431-441
JournalNutrition and Cancer
Volume67
Issue number3
Early online date3 Feb 2015
DOIs
Publication statusPublished - Apr 2015

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Breast Feeding
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Brain Neoplasms
Odds Ratio
Confidence Intervals
Population Control
Case-Control Studies
Neoplasms
Logistic Models
Mothers
Parturition
Pediatrics
Diet
Food

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Greenop, Kathryn ; Bailey, Helen ; Miller, M.R. ; Scott, R.J. ; Attia, J.R. ; Ashton, L.J. ; Downie, P. ; Armstrong, B.K. ; Milne, Elizabeth. / Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. In: Nutrition and Cancer. 2015 ; Vol. 67, No. 3. pp. 431-441.
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Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. / Greenop, Kathryn; Bailey, Helen; Miller, M.R.; Scott, R.J.; Attia, J.R.; Ashton, L.J.; Downie, P.; Armstrong, B.K.; Milne, Elizabeth.

In: Nutrition and Cancer, Vol. 67, No. 3, 04.2015, p. 431-441.

Research output: Contribution to journalArticle

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AB - © 2015 Taylor & Francis Group, LLC. Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.

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