Breast cancer risk and the interaction between adolescent body size and weight gain in later life: A case-control study

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Abstract

© 2016 Elsevier LtdBackground While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. Methods We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women. Logistic regression adjusted for the matching factor age and further potential confounders was used. Results Adolescent body leanness in postmenopausal women and excess adult weight gain in all study participants were associated with an increased breast cancer risk with an odds ratio [95% confidence interval] of 1.29 [1.08,1.54] and 1.31 [1.09,1.59], respectively. Interaction analyses restricted to postmenopausal women revealed an increased risk of breast cancer in those who were lean during adolescence and gained excess weight during adulthood (odds ratio [95% confidence interval]: 1.52 [1.19,1.95]) but not in women who were lean during adolescence and did not gain excess weight during adulthood (1.20 [0.97,1.48]) and not in women who were not lean during adolescence and but gained excess weight during adulthood (1.10 [0.95,1.27]) compared to postmenopausal women who were neither lean during adolescence nor gained excess weight. Conclusion In postmenopausal women adolescent leanness was only associated with increased breast cancer risk when excess weight was gained during adulthood.
Original languageEnglish
Pages (from-to)135-144
JournalCancer Epidemiology
Volume45
DOIs
Publication statusPublished - 1 Dec 2016

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Body Size
Weight Gain
Case-Control Studies
Body Weight
Breast Neoplasms
Weights and Measures
Thinness
Odds Ratio
Confidence Intervals
Age Factors
Estrogens
Logistic Models
Population

Cite this

@article{c628c0c519f84c0588e4f193cffbd6c0,
title = "Breast cancer risk and the interaction between adolescent body size and weight gain in later life: A case-control study",
abstract = "{\circledC} 2016 Elsevier LtdBackground While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. Methods We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women. Logistic regression adjusted for the matching factor age and further potential confounders was used. Results Adolescent body leanness in postmenopausal women and excess adult weight gain in all study participants were associated with an increased breast cancer risk with an odds ratio [95{\%} confidence interval] of 1.29 [1.08,1.54] and 1.31 [1.09,1.59], respectively. Interaction analyses restricted to postmenopausal women revealed an increased risk of breast cancer in those who were lean during adolescence and gained excess weight during adulthood (odds ratio [95{\%} confidence interval]: 1.52 [1.19,1.95]) but not in women who were lean during adolescence and did not gain excess weight during adulthood (1.20 [0.97,1.48]) and not in women who were not lean during adolescence and but gained excess weight during adulthood (1.10 [0.95,1.27]) compared to postmenopausal women who were neither lean during adolescence nor gained excess weight. Conclusion In postmenopausal women adolescent leanness was only associated with increased breast cancer risk when excess weight was gained during adulthood.",
author = "I. Florath and D. Sarink and Christobel Saunders and Jane Heyworth and Lin Fritschi",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.canep.2016.10.016",
language = "English",
volume = "45",
pages = "135--144",
journal = "Cancer Detection and Prevention",
issn = "0361-090X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Breast cancer risk and the interaction between adolescent body size and weight gain in later life: A case-control study

AU - Florath, I.

AU - Sarink, D.

AU - Saunders, Christobel

AU - Heyworth, Jane

AU - Fritschi, Lin

PY - 2016/12/1

Y1 - 2016/12/1

N2 - © 2016 Elsevier LtdBackground While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. Methods We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women. Logistic regression adjusted for the matching factor age and further potential confounders was used. Results Adolescent body leanness in postmenopausal women and excess adult weight gain in all study participants were associated with an increased breast cancer risk with an odds ratio [95% confidence interval] of 1.29 [1.08,1.54] and 1.31 [1.09,1.59], respectively. Interaction analyses restricted to postmenopausal women revealed an increased risk of breast cancer in those who were lean during adolescence and gained excess weight during adulthood (odds ratio [95% confidence interval]: 1.52 [1.19,1.95]) but not in women who were lean during adolescence and did not gain excess weight during adulthood (1.20 [0.97,1.48]) and not in women who were not lean during adolescence and but gained excess weight during adulthood (1.10 [0.95,1.27]) compared to postmenopausal women who were neither lean during adolescence nor gained excess weight. Conclusion In postmenopausal women adolescent leanness was only associated with increased breast cancer risk when excess weight was gained during adulthood.

AB - © 2016 Elsevier LtdBackground While the breast cancer risk associated with increasing adult BMI in postmenopausal women can be explained by increases in concentrations of endogenous estrogens the biologic mechanisms behind the inverse association between adolescent BMI and breast cancer risk are still a subject of controversial debate. Methods We investigated the association of breast cancer with body size and changes in body size across life time estimated by age-specific BMI Z scores and changes in BMI Z scores from teenage years to middle age in an age-matched population-based case-control study of 2994 Australian women. Logistic regression adjusted for the matching factor age and further potential confounders was used. Results Adolescent body leanness in postmenopausal women and excess adult weight gain in all study participants were associated with an increased breast cancer risk with an odds ratio [95% confidence interval] of 1.29 [1.08,1.54] and 1.31 [1.09,1.59], respectively. Interaction analyses restricted to postmenopausal women revealed an increased risk of breast cancer in those who were lean during adolescence and gained excess weight during adulthood (odds ratio [95% confidence interval]: 1.52 [1.19,1.95]) but not in women who were lean during adolescence and did not gain excess weight during adulthood (1.20 [0.97,1.48]) and not in women who were not lean during adolescence and but gained excess weight during adulthood (1.10 [0.95,1.27]) compared to postmenopausal women who were neither lean during adolescence nor gained excess weight. Conclusion In postmenopausal women adolescent leanness was only associated with increased breast cancer risk when excess weight was gained during adulthood.

U2 - 10.1016/j.canep.2016.10.016

DO - 10.1016/j.canep.2016.10.016

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VL - 45

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JO - Cancer Detection and Prevention

JF - Cancer Detection and Prevention

SN - 0361-090X

ER -