Breast Cancer and Transplantation

G. Wong, E. Au, S. V. Badve, W. H. Lim

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Breast cancer is an important cancer among solid organ transplant recipients. While the incidence of breast cancer in solid organ transplant recipients is comparable to the age-matched general population, the outcomes are generally poor. Interventions such as cancer screening that preclude the development of late-stage disease through early detection are not well studied, and clinical practice guidelines for cancer screening rely solely on recommendations from the general population. Among patients with a prior breast cancer history, disease recurrence after transplantation is a rare but fearful event. Once disease recurs, the risk of death is high. The focus of this review is to present the epidemiology of breast cancer in solid organ transplant recipients, screening and preventive strategies for those who may be at risk, novel genomic profiling for determining tumor progression, and the newer targeted interventions for recipients who have developed breast cancers after solid organ transplantation.

Original languageEnglish
Pages (from-to)2243-2253
Number of pages11
JournalAmerican Journal of Transplantation
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2017
Externally publishedYes

Cite this

Wong, G. ; Au, E. ; Badve, S. V. ; Lim, W. H. / Breast Cancer and Transplantation. In: American Journal of Transplantation. 2017 ; Vol. 17, No. 9. pp. 2243-2253.
@article{2ee2bb6e554448d5817641e444db983e,
title = "Breast Cancer and Transplantation",
abstract = "Breast cancer is an important cancer among solid organ transplant recipients. While the incidence of breast cancer in solid organ transplant recipients is comparable to the age-matched general population, the outcomes are generally poor. Interventions such as cancer screening that preclude the development of late-stage disease through early detection are not well studied, and clinical practice guidelines for cancer screening rely solely on recommendations from the general population. Among patients with a prior breast cancer history, disease recurrence after transplantation is a rare but fearful event. Once disease recurs, the risk of death is high. The focus of this review is to present the epidemiology of breast cancer in solid organ transplant recipients, screening and preventive strategies for those who may be at risk, novel genomic profiling for determining tumor progression, and the newer targeted interventions for recipients who have developed breast cancers after solid organ transplantation.",
keywords = "CLINICAL-PRACTICE GUIDELINES, OF-THE-LITERATURE, KIDNEY-TRANSPLANT, CHECKPOINT INHIBITORS, LIVER-TRANSPLANTATION, ORGAN-TRANSPLANTATION, COLORECTAL-CANCER, RECIPIENTS, RISK, POPULATION",
author = "G. Wong and E. Au and Badve, {S. V.} and Lim, {W. H.}",
year = "2017",
month = "9",
doi = "10.1111/ajt.14368",
language = "English",
volume = "17",
pages = "2243--2253",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "John Wiley & Sons",
number = "9",

}

Breast Cancer and Transplantation. / Wong, G.; Au, E.; Badve, S. V.; Lim, W. H.

In: American Journal of Transplantation, Vol. 17, No. 9, 09.2017, p. 2243-2253.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Breast Cancer and Transplantation

AU - Wong, G.

AU - Au, E.

AU - Badve, S. V.

AU - Lim, W. H.

PY - 2017/9

Y1 - 2017/9

N2 - Breast cancer is an important cancer among solid organ transplant recipients. While the incidence of breast cancer in solid organ transplant recipients is comparable to the age-matched general population, the outcomes are generally poor. Interventions such as cancer screening that preclude the development of late-stage disease through early detection are not well studied, and clinical practice guidelines for cancer screening rely solely on recommendations from the general population. Among patients with a prior breast cancer history, disease recurrence after transplantation is a rare but fearful event. Once disease recurs, the risk of death is high. The focus of this review is to present the epidemiology of breast cancer in solid organ transplant recipients, screening and preventive strategies for those who may be at risk, novel genomic profiling for determining tumor progression, and the newer targeted interventions for recipients who have developed breast cancers after solid organ transplantation.

AB - Breast cancer is an important cancer among solid organ transplant recipients. While the incidence of breast cancer in solid organ transplant recipients is comparable to the age-matched general population, the outcomes are generally poor. Interventions such as cancer screening that preclude the development of late-stage disease through early detection are not well studied, and clinical practice guidelines for cancer screening rely solely on recommendations from the general population. Among patients with a prior breast cancer history, disease recurrence after transplantation is a rare but fearful event. Once disease recurs, the risk of death is high. The focus of this review is to present the epidemiology of breast cancer in solid organ transplant recipients, screening and preventive strategies for those who may be at risk, novel genomic profiling for determining tumor progression, and the newer targeted interventions for recipients who have developed breast cancers after solid organ transplantation.

KW - CLINICAL-PRACTICE GUIDELINES

KW - OF-THE-LITERATURE

KW - KIDNEY-TRANSPLANT

KW - CHECKPOINT INHIBITORS

KW - LIVER-TRANSPLANTATION

KW - ORGAN-TRANSPLANTATION

KW - COLORECTAL-CANCER

KW - RECIPIENTS

KW - RISK

KW - POPULATION

U2 - 10.1111/ajt.14368

DO - 10.1111/ajt.14368

M3 - Review article

VL - 17

SP - 2243

EP - 2253

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 9

ER -