Brain ventricular volume changes induced by long-duration spaceflight

Angelique Van Ombergen, Steven Jillings, Ben Jeurissen, Elena Tomilovskaya, Alena Rumshiskaya, Liudmila Litvinova, Inna Nosikova, Ekaterina V Pechenkova, Ilya Rukavishnikov, Olga Manko, Sergey Danylichev, R. Maxine Rühl, Inessa B. Kozlovskaya, Stefan Sunaert, Paul M. Parizel, Valentin Sinitsyn, Steven Laureys, Jan Sijbers, Peter Zu Eulenburg, Floris L. Wuyts

Research output: Contribution to journalArticle

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Abstract

Long-duration spaceflight induces detrimental changes in human physiology. Its residual effects and mechanisms remain unclear. We prospectively investigated the changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest analysis on structural brain scans. Cosmonaut MRI data were investigated preflight (n = 11), postflight (n = 11), and at long-term follow-up 7 mo after landing (n = 7). Post hoc analyses revealed a significant difference between preflight and postflight values for all supratentorial ventricular structures, i.e., lateral ventricle (mean % change +/- SE = 13.3 +/- 1.9), third ventricle (mean % change +/- SE = 10.4 +/- 1.1), and the total ventricular volume (mean % change +/- SE = 11.6 +/- 1.5) (all P <0.0001), with higher volumes at postflight. At follow-up, these structures did not quite reach baseline levels, with still residual increases in volume for the lateral ventricle (mean % change +/- SE = 7.7 +/- 1.6; P = 0.0009), the third ventricle (mean % change +/- SE = 4.7 +/- 1.3; P = 0.0063), and the total ventricular volume (mean % change +/- SE = 6.4 +/- 1.3; P = 0.0008). This spatiotemporal pattern of CSF compartment enlargement and recovery points to a reduced CSF resorption in microgravity as the underlying cause. Our results warrant more detailed and longer longitudinal follow-up. The clinical impact of our findings on the long-term cosmonauts' health and their relation to ocular changes reported in space travelers requires further prospective studies.

Original languageEnglish
Pages (from-to)10531-10536
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number21
DOIs
Publication statusPublished - 21 May 2019
Externally publishedYes

Cite this

Van Ombergen, A., Jillings, S., Jeurissen, B., Tomilovskaya, E., Rumshiskaya, A., Litvinova, L., ... Wuyts, F. L. (2019). Brain ventricular volume changes induced by long-duration spaceflight. Proceedings of the National Academy of Sciences of the United States of America, 116(21), 10531-10536. https://doi.org/10.1073/pnas.1820354116
Van Ombergen, Angelique ; Jillings, Steven ; Jeurissen, Ben ; Tomilovskaya, Elena ; Rumshiskaya, Alena ; Litvinova, Liudmila ; Nosikova, Inna ; Pechenkova, Ekaterina V ; Rukavishnikov, Ilya ; Manko, Olga ; Danylichev, Sergey ; Rühl, R. Maxine ; Kozlovskaya, Inessa B. ; Sunaert, Stefan ; Parizel, Paul M. ; Sinitsyn, Valentin ; Laureys, Steven ; Sijbers, Jan ; Eulenburg, Peter Zu ; Wuyts, Floris L. / Brain ventricular volume changes induced by long-duration spaceflight. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 21. pp. 10531-10536.
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Van Ombergen, A, Jillings, S, Jeurissen, B, Tomilovskaya, E, Rumshiskaya, A, Litvinova, L, Nosikova, I, Pechenkova, EV, Rukavishnikov, I, Manko, O, Danylichev, S, Rühl, RM, Kozlovskaya, IB, Sunaert, S, Parizel, PM, Sinitsyn, V, Laureys, S, Sijbers, J, Eulenburg, PZ & Wuyts, FL 2019, 'Brain ventricular volume changes induced by long-duration spaceflight' Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 21, pp. 10531-10536. https://doi.org/10.1073/pnas.1820354116

Brain ventricular volume changes induced by long-duration spaceflight. / Van Ombergen, Angelique; Jillings, Steven; Jeurissen, Ben; Tomilovskaya, Elena; Rumshiskaya, Alena; Litvinova, Liudmila; Nosikova, Inna; Pechenkova, Ekaterina V; Rukavishnikov, Ilya; Manko, Olga; Danylichev, Sergey; Rühl, R. Maxine; Kozlovskaya, Inessa B.; Sunaert, Stefan; Parizel, Paul M.; Sinitsyn, Valentin; Laureys, Steven; Sijbers, Jan; Eulenburg, Peter Zu; Wuyts, Floris L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 21, 21.05.2019, p. 10531-10536.

Research output: Contribution to journalArticle

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T1 - Brain ventricular volume changes induced by long-duration spaceflight

AU - Van Ombergen, Angelique

AU - Jillings, Steven

AU - Jeurissen, Ben

AU - Tomilovskaya, Elena

AU - Rumshiskaya, Alena

AU - Litvinova, Liudmila

AU - Nosikova, Inna

AU - Pechenkova, Ekaterina V

AU - Rukavishnikov, Ilya

AU - Manko, Olga

AU - Danylichev, Sergey

AU - Rühl, R. Maxine

AU - Kozlovskaya, Inessa B.

AU - Sunaert, Stefan

AU - Parizel, Paul M.

AU - Sinitsyn, Valentin

AU - Laureys, Steven

AU - Sijbers, Jan

AU - Eulenburg, Peter Zu

AU - Wuyts, Floris L.

PY - 2019/5/21

Y1 - 2019/5/21

N2 - Long-duration spaceflight induces detrimental changes in human physiology. Its residual effects and mechanisms remain unclear. We prospectively investigated the changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest analysis on structural brain scans. Cosmonaut MRI data were investigated preflight (n = 11), postflight (n = 11), and at long-term follow-up 7 mo after landing (n = 7). Post hoc analyses revealed a significant difference between preflight and postflight values for all supratentorial ventricular structures, i.e., lateral ventricle (mean % change +/- SE = 13.3 +/- 1.9), third ventricle (mean % change +/- SE = 10.4 +/- 1.1), and the total ventricular volume (mean % change +/- SE = 11.6 +/- 1.5) (all P <0.0001), with higher volumes at postflight. At follow-up, these structures did not quite reach baseline levels, with still residual increases in volume for the lateral ventricle (mean % change +/- SE = 7.7 +/- 1.6; P = 0.0009), the third ventricle (mean % change +/- SE = 4.7 +/- 1.3; P = 0.0063), and the total ventricular volume (mean % change +/- SE = 6.4 +/- 1.3; P = 0.0008). This spatiotemporal pattern of CSF compartment enlargement and recovery points to a reduced CSF resorption in microgravity as the underlying cause. Our results warrant more detailed and longer longitudinal follow-up. The clinical impact of our findings on the long-term cosmonauts' health and their relation to ocular changes reported in space travelers requires further prospective studies.

AB - Long-duration spaceflight induces detrimental changes in human physiology. Its residual effects and mechanisms remain unclear. We prospectively investigated the changes in cerebrospinal fluid (CSF) volume of the brain ventricular regions in space crew by means of a region of interest analysis on structural brain scans. Cosmonaut MRI data were investigated preflight (n = 11), postflight (n = 11), and at long-term follow-up 7 mo after landing (n = 7). Post hoc analyses revealed a significant difference between preflight and postflight values for all supratentorial ventricular structures, i.e., lateral ventricle (mean % change +/- SE = 13.3 +/- 1.9), third ventricle (mean % change +/- SE = 10.4 +/- 1.1), and the total ventricular volume (mean % change +/- SE = 11.6 +/- 1.5) (all P <0.0001), with higher volumes at postflight. At follow-up, these structures did not quite reach baseline levels, with still residual increases in volume for the lateral ventricle (mean % change +/- SE = 7.7 +/- 1.6; P = 0.0009), the third ventricle (mean % change +/- SE = 4.7 +/- 1.3; P = 0.0063), and the total ventricular volume (mean % change +/- SE = 6.4 +/- 1.3; P = 0.0008). This spatiotemporal pattern of CSF compartment enlargement and recovery points to a reduced CSF resorption in microgravity as the underlying cause. Our results warrant more detailed and longer longitudinal follow-up. The clinical impact of our findings on the long-term cosmonauts' health and their relation to ocular changes reported in space travelers requires further prospective studies.

KW - Brain

KW - CSF

KW - Microgravity

KW - Spaceflight

KW - Ventricles

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U2 - 10.1073/pnas.1820354116

DO - 10.1073/pnas.1820354116

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Van Ombergen A, Jillings S, Jeurissen B, Tomilovskaya E, Rumshiskaya A, Litvinova L et al. Brain ventricular volume changes induced by long-duration spaceflight. Proceedings of the National Academy of Sciences of the United States of America. 2019 May 21;116(21):10531-10536. https://doi.org/10.1073/pnas.1820354116