Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis

Amir Hossein Aalami, Hossein Abdeahad, Ali Shoghi, Mohammad Mesgari, Amir Amirabadi, Amirhossein Sahebkar

Research output: Contribution to journalArticlepeer-review

13 Citations (Web of Science)


Purpose: Brain tumors (BT) are among the most prevalent cancers in recent years. Various studies have examined the diagnostic role of microRNAs in different diseases; however, their diagnostic role in BT has not been comprehensively investigated. This meta-analysis was performed to assess microRNAs in the blood of patients with BTs accurately. Methods: Twenty-six eligible studies were included for analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under curve (AUC), Q*index, summary receiver-operating characteristic (SROC) were assessed using the Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.3.3 software. Results: The diagnostic accuracy of microRNA was high in identifying BT based on the pooled sensitivity 0.82 (95%CI: 0.816–0.84), specificity 0.82 (95%CI: 0.817–0.84), PLR 5.101 (95%CI: 3.99–6.51), NLR 0.187 (95%CI: 0.149–0.236), DOR 34.07 (95%CI: 22.56–51.43) as well as AUC (0.92), and Q*-index (0.86). Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR. Conclusion: This meta-analysis suggested that circulating microRNAs might be potential markers for noninvasive early detection of BT.

Original languageEnglish
Pages (from-to)201-211
Number of pages11
Issue number2
Publication statusE-pub ahead of print - 11 Jan 2022


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