Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu; Youming Long; Shisi Wang; Wanming Hu; Jian Zhou; Huiming Xu; Chen Chen; Yangmei Ou; Zhengqi Lu; Alexander Y. Lau; Xinhua Yu; Allan G. Kermode; Wei Qiu

doi:10.1002/acn3.712

Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu, Youming Long, Shisi Wang, Wanming Hu, Jian Zhou, Huiming Xu, Chen Chen, Yangmei Ou, Zhengqi Lu, Alexander Y. Lau, Xinhua Yu, Allan G. Kermode, Wei Qiu

Centre for Neuromuscular and Neurological Disorders (Perron Institute)

Research output: Contribution to journal › Article › peer-review

22 Citations (Web of Science)

Abstract

Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

Original language	English
Pages (from-to)	392-396
Number of pages	5
Journal	Annals of Clinical and Translational Neurology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1002/acn3.712
Publication status	Published - 1 Feb 2019

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title = "Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor",

abstract = "Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.",

author = "Yaqing Shu and Youming Long and Shisi Wang and Wanming Hu and Jian Zhou and Huiming Xu and Chen Chen and Yangmei Ou and Zhengqi Lu and Lau, {Alexander Y.} and Xinhua Yu and Kermode, {Allan G.} and Wei Qiu",

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T1 - Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

AU - Shu, Yaqing

AU - Long, Youming

AU - Wang, Shisi

AU - Hu, Wanming

AU - Zhou, Jian

AU - Xu, Huiming

AU - Chen, Chen

AU - Ou, Yangmei

AU - Lu, Zhengqi

AU - Lau, Alexander Y.

AU - Yu, Xinhua

AU - Kermode, Allan G.

AU - Qiu, Wei

PY - 2019/2/1

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N2 - Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

AB - Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

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Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Abstract

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