Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu, Youming Long, Shisi Wang, Wanming Hu, Jian Zhou, Huiming Xu, Chen Chen, Yangmei Ou, Zhengqi Lu, Alexander Y. Lau, Xinhua Yu, Allan G. Kermode, Wei Qiu

Research output: Contribution to journalArticle

Abstract

Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

Original languageEnglish
Pages (from-to)392-396
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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Myelin-Oligodendrocyte Glycoprotein
Antibodies
Brain
Steroids
Biopsy
Encephalomyelitis
Demyelinating Diseases
Immunotherapy
Multiple Sclerosis
Macrophages
Pathology
T-Lymphocytes
Rituximab
Therapeutics

Cite this

Shu, Yaqing ; Long, Youming ; Wang, Shisi ; Hu, Wanming ; Zhou, Jian ; Xu, Huiming ; Chen, Chen ; Ou, Yangmei ; Lu, Zhengqi ; Lau, Alexander Y. ; Yu, Xinhua ; Kermode, Allan G. ; Qiu, Wei. / Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor. In: Annals of Clinical and Translational Neurology. 2019 ; Vol. 6, No. 2. pp. 392-396.
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abstract = "Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.",
author = "Yaqing Shu and Youming Long and Shisi Wang and Wanming Hu and Jian Zhou and Huiming Xu and Chen Chen and Yangmei Ou and Zhengqi Lu and Lau, {Alexander Y.} and Xinhua Yu and Kermode, {Allan G.} and Wei Qiu",
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Shu, Y, Long, Y, Wang, S, Hu, W, Zhou, J, Xu, H, Chen, C, Ou, Y, Lu, Z, Lau, AY, Yu, X, Kermode, AG & Qiu, W 2019, 'Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor' Annals of Clinical and Translational Neurology, vol. 6, no. 2, pp. 392-396. https://doi.org/10.1002/acn3.712

Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor. / Shu, Yaqing; Long, Youming; Wang, Shisi; Hu, Wanming; Zhou, Jian; Xu, Huiming; Chen, Chen; Ou, Yangmei; Lu, Zhengqi; Lau, Alexander Y.; Yu, Xinhua; Kermode, Allan G.; Qiu, Wei.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 2, 01.02.2019, p. 392-396.

Research output: Contribution to journalArticle

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