Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor

Yaqing Shu, Youming Long, Shisi Wang, Wanming Hu, Jian Zhou, Huiming Xu, Chen Chen, Yangmei Ou, Zhengqi Lu, Alexander Y. Lau, Xinhua Yu, Allan G. Kermode, Wei Qiu

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.

Original languageEnglish
Pages (from-to)392-396
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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