@article{de3b7b15718049c7be8759d8cd7cfdc9,
title = "Brain Connectivity, Acute Post-Concussion Symptoms, and Cognition in Adults With Concussion: A Quantitative Electroencephalography Study",
abstract = "Mild traumatic brain injury (mTBI) accounts for 80-90% of all TBI. Post-mTBI symptoms are measured using the Post-Concussion Symptom Scale (PCSS); however, symptom heterogeneity limits specificity. Better understanding of the neuropathophysiology underlying post-concussion symptoms could enhance diagnostic accuracy. We explored the association between network connectivity, PCSS and neuropsychological functioning within 7 days post-mTBI. We hypothesized that network dysregulation would (a) correlate positively with PCSS scores and (b) correlate negatively with cognitive performance; and that (c) cognitive performance would correlate negatively with PCSS scores. Network activity was measured in 19 participants aged 21 to 65, following a medically diagnosed mTBI. Quantitative electroencephalography (qEEG) measured default mode, salience, and frontoparietal networks, while cognition was measured via neuropsychological assessment. Hypothesis (a) was not supported. Of the cognitive domains, support was only found for an association between network dysfunction and immediate memory. There was no association between neuropsychological performance and PCSS scores. PCSS scores were not a sensitive indicator of neuropsychological status and did not reflect the status of underlying brain network regulation. This study provides preliminary evidence for immediate memory as an indicator of altered network connectivity in acute mTBI. Evaluating neurophysiological and cognitive impacts of mTBI may improve understanding of individual recovery needs.",
keywords = "default mode network, frontoparietal network, post-concussion symptoms, quantitative electroencephalography, salience network",
author = "Francesca Buhagiar and Melinda Fitzgerald and Hellewell, {Sarah C.} and Jason Bell and Samantha Moore and Gozt, {Aleksandra K.} and Jacinta Thorne and Elizabeth Thomas and Antonio Celenza and Dan Xu and Suzanne Robinson and Gill Cowen and Michael Bynevelt and Fatovich, {Daniel M.} and Pestell, {Carmela F.}",
note = "Funding Information: Melinda Fitzgerald is the Chief Executive Officer of the charitable organization Connectivity—Traumatic Brain Injury Australia. Funding for this research project was provided by the Neurotrauma Research Program WA (NRP) and was funded by the State Government of Western Australia through the Department of Health. We thank the Perron Institute for Neurological and Translational Science for its support for this research through the award of a Perron Internal Grant. The funding agencies did not have any role in the planning, conduct or writing of this manuscript. Funding Information: This study would not have been possible without the wider Concussion Recovery Study (CREST) team members including Melissa Licari, Alexander Ring, Glenn Arendts, Ben Smedley, Sjinene Van Schalkwyk, Philip Brooks, John Iliff, Ashes Mukherjee, Stephen Honeybul, Shaun Markovic, and Anoek Van Houselt. Sincere thanks to the CREST participants for their contributions to our research. Publisher Copyright: Copyright: {\textcopyright} 2023. Buhagiar et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY).",
year = "2023",
month = jun,
day = "29",
doi = "10.15540/nr.10.2.94",
language = "English",
volume = "10",
pages = "94--117",
journal = "NeuroRegulation",
publisher = "International Society for Neurofeedback & Research",
number = "2",
}