Brachial blood pressure but not carotid arterial waveforms predict cardiovascular events in elderly female hypertensives

A.M. Dart, C.D. Gatzka, B.A. Kingwell, K. Willson, J.D. Cameron, Y-L. Liang, K.L. Berry, L.M.H. Wing, C.M. Reid, P. Ryan, Lawrence Beilin

    Research output: Contribution to journalArticle

    147 Citations (Scopus)

    Abstract

    Central arterial waveforms and related indices of large artery properties can be determined with relative ease. This would make them an attractive adjunct in the risk stratification for cardiovascular disease. Although they have been associated with some classical risk factors and the presence of coronary disease, their prospective value in predicting cardiovascular outcomes is unknown. The present study determined the relative predictive value for cardiovascular disease-free survival of large artery properties as compared with noninvasive brachial blood pressure alone in a population of elderly female hypertensive subjects. We measured systemic arterial compliance, central systolic pressure, and carotid augmentation index in a subset of female participants in the Second Australian National Blood Pressure Study (untreated blood pressure 169/88±12/8 mm Hg). There were a total of 53 defined events during a median of 4.1 years of follow-up in 484 women with complete measurements. Although baseline blood pressures at the brachial artery predicted cardiovascular disease-free survival (hazard ratio [HR], 2.3; 95% CI, 1.3 to 4.1 for pulse pressure 81 versus
    Original languageEnglish
    Pages (from-to)785-790
    JournalHypertension
    Volume47
    DOIs
    Publication statusPublished - 2006

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