Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

J.B. Richards, F. Rivadeneira, M. Inouye, T.M. Pastinen, N. Soranzo, Scott Wilson, T. Andrew, M. Falchi, R. Gwilliam, K.R. Ahmadi, A.M. Valdes, P. Arp, P. Whittaker, D.J. Verlaan, M. Jhamai, V. Kumanduri, M. Moorhouse, J.B. Van Meurs, A. Hofman, H.A.P. Pols & 8 others D. Hart, G. Zhai, B.S. Kato, B.H. Mullin, F. Zhang, P. Deloukas, A.G. Uitterlinden, T.D. Spector

Research output: Contribution to journalArticle

475 Citations (Scopus)

Abstract

Background: Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density.Methods: In this genome-wide association study, we identified the most promising of 314 075 single nucleotide polymorphisms (SNPs) in 2094 women in a UK study. We then tested these SNPs for replication in 6463 people from three other cohorts in western Europe. We also investigated allelic expression in lymphoblast cell lines. We tested the association between the replicated SNPs and osteoporotic fractures with data from two studies. Findings: We identified genome-wide evidence for an association between bone mineral density and two SNPs (p
Original languageEnglish
Pages (from-to)online - approx 5-20pp
JournalThe Lancet
Volume371
Issue number9623
DOIs
Publication statusPublished - 2008

Fingerprint

Osteoporotic Fractures
Genome-Wide Association Study
Bone Density
Osteoporosis
Single Nucleotide Polymorphism
Genetic Loci
Genome
Cell Line

Cite this

Richards, J. B., Rivadeneira, F., Inouye, M., Pastinen, T. M., Soranzo, N., Wilson, S., ... Spector, T. D. (2008). Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. The Lancet, 371(9623), online - approx 5-20pp. https://doi.org/10.1016/S0140-6736(08)60599-1
Richards, J.B. ; Rivadeneira, F. ; Inouye, M. ; Pastinen, T.M. ; Soranzo, N. ; Wilson, Scott ; Andrew, T. ; Falchi, M. ; Gwilliam, R. ; Ahmadi, K.R. ; Valdes, A.M. ; Arp, P. ; Whittaker, P. ; Verlaan, D.J. ; Jhamai, M. ; Kumanduri, V. ; Moorhouse, M. ; Van Meurs, J.B. ; Hofman, A. ; Pols, H.A.P. ; Hart, D. ; Zhai, G. ; Kato, B.S. ; Mullin, B.H. ; Zhang, F. ; Deloukas, P. ; Uitterlinden, A.G. ; Spector, T.D. / Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. In: The Lancet. 2008 ; Vol. 371, No. 9623. pp. online - approx 5-20pp.
@article{8bddc9cf1f234c53bded843223943b86,
title = "Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study",
abstract = "Background: Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density.Methods: In this genome-wide association study, we identified the most promising of 314 075 single nucleotide polymorphisms (SNPs) in 2094 women in a UK study. We then tested these SNPs for replication in 6463 people from three other cohorts in western Europe. We also investigated allelic expression in lymphoblast cell lines. We tested the association between the replicated SNPs and osteoporotic fractures with data from two studies. Findings: We identified genome-wide evidence for an association between bone mineral density and two SNPs (p",
author = "J.B. Richards and F. Rivadeneira and M. Inouye and T.M. Pastinen and N. Soranzo and Scott Wilson and T. Andrew and M. Falchi and R. Gwilliam and K.R. Ahmadi and A.M. Valdes and P. Arp and P. Whittaker and D.J. Verlaan and M. Jhamai and V. Kumanduri and M. Moorhouse and {Van Meurs}, J.B. and A. Hofman and H.A.P. Pols and D. Hart and G. Zhai and B.S. Kato and B.H. Mullin and F. Zhang and P. Deloukas and A.G. Uitterlinden and T.D. Spector",
year = "2008",
doi = "10.1016/S0140-6736(08)60599-1",
language = "English",
volume = "371",
pages = "online -- approx 5--20pp",
journal = "Lancet",
issn = "0140-6736",
publisher = "Academic Press",
number = "9623",

}

Richards, JB, Rivadeneira, F, Inouye, M, Pastinen, TM, Soranzo, N, Wilson, S, Andrew, T, Falchi, M, Gwilliam, R, Ahmadi, KR, Valdes, AM, Arp, P, Whittaker, P, Verlaan, DJ, Jhamai, M, Kumanduri, V, Moorhouse, M, Van Meurs, JB, Hofman, A, Pols, HAP, Hart, D, Zhai, G, Kato, BS, Mullin, BH, Zhang, F, Deloukas, P, Uitterlinden, AG & Spector, TD 2008, 'Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study' The Lancet, vol. 371, no. 9623, pp. online - approx 5-20pp. https://doi.org/10.1016/S0140-6736(08)60599-1

Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. / Richards, J.B.; Rivadeneira, F.; Inouye, M.; Pastinen, T.M.; Soranzo, N.; Wilson, Scott; Andrew, T.; Falchi, M.; Gwilliam, R.; Ahmadi, K.R.; Valdes, A.M.; Arp, P.; Whittaker, P.; Verlaan, D.J.; Jhamai, M.; Kumanduri, V.; Moorhouse, M.; Van Meurs, J.B.; Hofman, A.; Pols, H.A.P.; Hart, D.; Zhai, G.; Kato, B.S.; Mullin, B.H.; Zhang, F.; Deloukas, P.; Uitterlinden, A.G.; Spector, T.D.

In: The Lancet, Vol. 371, No. 9623, 2008, p. online - approx 5-20pp.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

AU - Richards, J.B.

AU - Rivadeneira, F.

AU - Inouye, M.

AU - Pastinen, T.M.

AU - Soranzo, N.

AU - Wilson, Scott

AU - Andrew, T.

AU - Falchi, M.

AU - Gwilliam, R.

AU - Ahmadi, K.R.

AU - Valdes, A.M.

AU - Arp, P.

AU - Whittaker, P.

AU - Verlaan, D.J.

AU - Jhamai, M.

AU - Kumanduri, V.

AU - Moorhouse, M.

AU - Van Meurs, J.B.

AU - Hofman, A.

AU - Pols, H.A.P.

AU - Hart, D.

AU - Zhai, G.

AU - Kato, B.S.

AU - Mullin, B.H.

AU - Zhang, F.

AU - Deloukas, P.

AU - Uitterlinden, A.G.

AU - Spector, T.D.

PY - 2008

Y1 - 2008

N2 - Background: Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density.Methods: In this genome-wide association study, we identified the most promising of 314 075 single nucleotide polymorphisms (SNPs) in 2094 women in a UK study. We then tested these SNPs for replication in 6463 people from three other cohorts in western Europe. We also investigated allelic expression in lymphoblast cell lines. We tested the association between the replicated SNPs and osteoporotic fractures with data from two studies. Findings: We identified genome-wide evidence for an association between bone mineral density and two SNPs (p

AB - Background: Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density.Methods: In this genome-wide association study, we identified the most promising of 314 075 single nucleotide polymorphisms (SNPs) in 2094 women in a UK study. We then tested these SNPs for replication in 6463 people from three other cohorts in western Europe. We also investigated allelic expression in lymphoblast cell lines. We tested the association between the replicated SNPs and osteoporotic fractures with data from two studies. Findings: We identified genome-wide evidence for an association between bone mineral density and two SNPs (p

U2 - 10.1016/S0140-6736(08)60599-1

DO - 10.1016/S0140-6736(08)60599-1

M3 - Article

VL - 371

SP - online - approx 5-20pp

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 9623

ER -

Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson S et al. Bone Mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. The Lancet. 2008;371(9623):online - approx 5-20pp. https://doi.org/10.1016/S0140-6736(08)60599-1