Body Temperature regulation determines immune reactions and species longevity

Research output: Chapter in Book/Conference paperChapter

Abstract

Temperature variations in various species have marked changes in body metabolism with higher temperatures associated with increased ageing. The observation that diets with calorie restriction are associated with species longevity are now related to the heat shock genes and body temperature regulation. Temperature increases that induce temperature dysregulation are connected to non alcoholic fatty liver disease (NAFLD) and the induction of diabetes and neurodegenerative diseases. Specific microRNAs are associated with heat shock gene regulation and override body temperature regulation relevant to adipose tissue-liver defects and insulin resistance. In geriatrics and diabetics complete heat shock gene inactivation is associated with mitochondrial apoptosis relevant to defective hepatic dietary fat and drug metabolism. The connections between core body temperature defects and autoimmune disease have now become important to determine programmed cell death in many cells and tissues with relevance to the global chronic disease epidemic and species survival.
Original languageEnglish
Title of host publicationHeat Shock Proteins in Neuroscience
EditorsA. A. Asea Alexzander, Punit Kaur
Chapter3
Number of pages15
Volume20
Publication statusAccepted/In press - 27 Nov 2019

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thermoregulation
heat stress
temperature
apoptosis
liver
genes
autoimmune diseases
fatty liver
neurodegenerative diseases
microRNA
chronic diseases
insulin resistance
dietary fat
lipid metabolism
body temperature
pharmacokinetics
adipose tissue
diabetes
inactivation
metabolism

Cite this

Martins, I. (Accepted/In press). Body Temperature regulation determines immune reactions and species longevity. In A. A. A. Alexzander, & P. Kaur (Eds.), Heat Shock Proteins in Neuroscience (Vol. 20)
Martins, Ian. / Body Temperature regulation determines immune reactions and species longevity. Heat Shock Proteins in Neuroscience. editor / A. A. Asea Alexzander ; Punit Kaur. Vol. 20 2019.
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Martins, I 2019, Body Temperature regulation determines immune reactions and species longevity. in AAA Alexzander & P Kaur (eds), Heat Shock Proteins in Neuroscience. vol. 20.

Body Temperature regulation determines immune reactions and species longevity. / Martins, Ian.

Heat Shock Proteins in Neuroscience. ed. / A. A. Asea Alexzander; Punit Kaur. Vol. 20 2019.

Research output: Chapter in Book/Conference paperChapter

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BT - Heat Shock Proteins in Neuroscience

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Martins I. Body Temperature regulation determines immune reactions and species longevity. In Alexzander AAA, Kaur P, editors, Heat Shock Proteins in Neuroscience. Vol. 20. 2019