Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project

Martha Sajatovic, Soham Rej, Osvaldo P. Almeida, Kursat Altinbas, Vicent Balanzá-Martínez, Izabela G. Barbosa, Alexandra J.M. Beunders, Hilary P. Blumberg, Farren B.S. Briggs, Annemiek Dols, Brent P. Forester, Orestes V. Forlenza, Ariel G. Gildengers, Esther Jimenez, Federica Klaus, Beny Lafer, Benoit Mulsant, Benson Mwangi, Paula Villela Nunes, Andrew T. OlagunjuStephen Oluwaniyi, Melis Orhan, Regan E. Patrick, Joaquim Radua, Tarek Rajji, Kaylee Sarna, Sigfried Schouws, Christian Simhandl, Harmehr Sekhon, Jair C. Soares, Ashley N. Sutherland, Antonio L. Teixeira, Shangying Tsai, Sonia Vidal-Rubio, Eduard Vieta, Joy Yala, Lisa T. Eyler

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. Design/Methods: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601). Results: Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning. Conclusions: In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.

Original languageEnglish
Article numbere6057
Number of pages10
JournalInternational Journal of Geriatric Psychiatry
Volume39
Issue number3
DOIs
Publication statusPublished - Mar 2024

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