Biotherapy and the Immune System in Ageing Science

Ian Martins

Research output: Contribution to specialist publicationLetterpeer-review

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Nutritional interventions have become important to delay the global diabetes and non-alcoholic fatty liver disease (NAFLD) pandemic. Nutritional biotherapy that activates the heat shock gene Sirtuin 1 (Sirt 1) is essential to prevent immunosenescence that is connected to mitochondrial apoptosis, chronic disease and neurodegeneration. Biotherapy to maintain the immune system require interventions that increase the consumption of Sirt 1 activators, functional foods and bioactive molecules. Low calorie diets are essential to maintain the Sirt 1 regulation of the immune system and autoimmune disease. Plasma Sirt 1 analysis should now be conductedon plasma samples to determine Sirt 1’s role in the defective immune system/autoimmune disease with relevance to diabetes nand NAFLD. Sirt 1 analysis with other immunological tests may assist with interpretations relevant to mitochondrial apoptosis and immunological disease. Drugs and immune reactions that regulate immune cell function are now linked to Sirt 1 activation with relevance to hepatic caffeine, xenobiotic and drug metabolism.
Original languageEnglish
Number of pages3
Specialist publicationActa Scientific Nutritional Health
Publication statusPublished - 27 Mar 2018


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